Continued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.

<h4>Background</h4>The skills used by winged insects to explore their environment are strongly dependent upon the integration of neurosensory information comprising visual, acoustic and olfactory signals. The neuronal architecture of the wing contains a vast array of different sensors wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Selim Ben Rokia-Mille, Sylvette Tinette, Gilbert Engler, Laury Arthaud, Sophie Tares, Alain Robichon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcceb7fba0b14978a9f2138115023dbd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dcceb7fba0b14978a9f2138115023dbd
record_format	dspace
spelling	oai:doaj.org-article:dcceb7fba0b14978a9f2138115023dbd2021-11-25T06:12:04ZContinued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.1932-620310.1371/journal.pone.0002395https://doaj.org/article/dcceb7fba0b14978a9f2138115023dbd2008-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18545694/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The skills used by winged insects to explore their environment are strongly dependent upon the integration of neurosensory information comprising visual, acoustic and olfactory signals. The neuronal architecture of the wing contains a vast array of different sensors which might convey information to the brain in order to guide the trajectories during flight. In Drosophila, the wing sensory cells are either chemoreceptors or mechanoreceptors and some of these sensors have as yet unknown functions. The axons of these two functionally distinct types of neurons are entangled, generating a single nerve. This simple and accessible coincidental signaling circuitry in Drosophila constitutes an excellent model system to investigate the developmental variability in relation to natural behavioral polymorphisms.<h4>Methodology/principal findings</h4>A fluorescent marker was generated in neurons at all stages of the Drosophila life cycle using a highly efficient and controlled genetic recombination system that can be induced in dividing precursor cells (MARCM system, flybase web site). It allows fluorescent signals in axons only when the neuroblasts and/or neuronal cell precursors like SOP (sensory organ precursors) undergo division during the precedent steps. We first show that a robust neurogenesis continues in the wing after the adults emerge from the pupae followed by an extensive axonal growth. Arguments are presented to suggest that this wing neurogenesis in the newborn adult flies was influenced by genetic determinants such as the frequency dependent for gene and by environmental cues such as population density.<h4>Conclusions</h4>We demonstrate that the neuronal architecture in the adult Drosophila wing is unfinished when the flies emerge from their pupae. This unexpected developmental step might be crucial for generating non-heritable variants and phenotypic plasticity. This might therefore constitute an advantage in an unstable ecological system and explain much regarding the ability of Drosophila to robustly adapt to their environment.Selim Ben Rokia-MilleSylvette TinetteGilbert EnglerLaury ArthaudSophie TaresAlain RobichonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 6, p e2395 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Selim Ben Rokia-Mille Sylvette Tinette Gilbert Engler Laury Arthaud Sophie Tares Alain Robichon Continued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.
description	<h4>Background</h4>The skills used by winged insects to explore their environment are strongly dependent upon the integration of neurosensory information comprising visual, acoustic and olfactory signals. The neuronal architecture of the wing contains a vast array of different sensors which might convey information to the brain in order to guide the trajectories during flight. In Drosophila, the wing sensory cells are either chemoreceptors or mechanoreceptors and some of these sensors have as yet unknown functions. The axons of these two functionally distinct types of neurons are entangled, generating a single nerve. This simple and accessible coincidental signaling circuitry in Drosophila constitutes an excellent model system to investigate the developmental variability in relation to natural behavioral polymorphisms.<h4>Methodology/principal findings</h4>A fluorescent marker was generated in neurons at all stages of the Drosophila life cycle using a highly efficient and controlled genetic recombination system that can be induced in dividing precursor cells (MARCM system, flybase web site). It allows fluorescent signals in axons only when the neuroblasts and/or neuronal cell precursors like SOP (sensory organ precursors) undergo division during the precedent steps. We first show that a robust neurogenesis continues in the wing after the adults emerge from the pupae followed by an extensive axonal growth. Arguments are presented to suggest that this wing neurogenesis in the newborn adult flies was influenced by genetic determinants such as the frequency dependent for gene and by environmental cues such as population density.<h4>Conclusions</h4>We demonstrate that the neuronal architecture in the adult Drosophila wing is unfinished when the flies emerge from their pupae. This unexpected developmental step might be crucial for generating non-heritable variants and phenotypic plasticity. This might therefore constitute an advantage in an unstable ecological system and explain much regarding the ability of Drosophila to robustly adapt to their environment.
format	article
author	Selim Ben Rokia-Mille Sylvette Tinette Gilbert Engler Laury Arthaud Sophie Tares Alain Robichon
author_facet	Selim Ben Rokia-Mille Sylvette Tinette Gilbert Engler Laury Arthaud Sophie Tares Alain Robichon
author_sort	Selim Ben Rokia-Mille
title	Continued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.
title_short	Continued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.
title_full	Continued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.
title_fullStr	Continued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.
title_full_unstemmed	Continued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.
title_sort	continued neurogenesis in adult drosophila as a mechanism for recruiting environmental cue-dependent variants.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/dcceb7fba0b14978a9f2138115023dbd
work_keys_str_mv	AT selimbenrokiamille continuedneurogenesisinadultdrosophilaasamechanismforrecruitingenvironmentalcuedependentvariants AT sylvettetinette continuedneurogenesisinadultdrosophilaasamechanismforrecruitingenvironmentalcuedependentvariants AT gilbertengler continuedneurogenesisinadultdrosophilaasamechanismforrecruitingenvironmentalcuedependentvariants AT lauryarthaud continuedneurogenesisinadultdrosophilaasamechanismforrecruitingenvironmentalcuedependentvariants AT sophietares continuedneurogenesisinadultdrosophilaasamechanismforrecruitingenvironmentalcuedependentvariants AT alainrobichon continuedneurogenesisinadultdrosophilaasamechanismforrecruitingenvironmentalcuedependentvariants
_version_	1718414074607304704

Continued neurogenesis in adult Drosophila as a mechanism for recruiting environmental cue-dependent variants.

Ejemplares similares