Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability

In mammalian cells, during transcription and replication, RNA:DNA hybrid structures known as R-loops can arise, posing as obstacles to replication fork progression. Here the authors reveal that the ATP-dependent chromatin remodelling INO80 complex promotes resolution of R-loops to prevent replicatio...

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Autores principales:	Lisa Prendergast, Urszula L. McClurg, Rossitsa Hristova, Rolando Berlinguer-Palmini, Sarah Greener, Katie Veitch, Inmaculada Hernandez, Philippe Pasero, Daniel Rico, Jonathan M. G. Higgins, Anastas Gospodinov, Manolis Papamichos-Chronakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0
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spelling	oai:doaj.org-article:dcd1345330a848728d9de1a0310ef7f02021-12-02T18:03:07ZResolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability10.1038/s41467-020-18306-x2041-1723https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f02020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18306-xhttps://doaj.org/toc/2041-1723In mammalian cells, during transcription and replication, RNA:DNA hybrid structures known as R-loops can arise, posing as obstacles to replication fork progression. Here the authors reveal that the ATP-dependent chromatin remodelling INO80 complex promotes resolution of R-loops to prevent replication associated DNA damage in cancer cells.Lisa PrendergastUrszula L. McClurgRossitsa HristovaRolando Berlinguer-PalminiSarah GreenerKatie VeitchInmaculada HernandezPhilippe PaseroDaniel RicoJonathan M. G. HigginsAnastas GospodinovManolis Papamichos-ChronakisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lisa Prendergast Urszula L. McClurg Rossitsa Hristova Rolando Berlinguer-Palmini Sarah Greener Katie Veitch Inmaculada Hernandez Philippe Pasero Daniel Rico Jonathan M. G. Higgins Anastas Gospodinov Manolis Papamichos-Chronakis Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
description	In mammalian cells, during transcription and replication, RNA:DNA hybrid structures known as R-loops can arise, posing as obstacles to replication fork progression. Here the authors reveal that the ATP-dependent chromatin remodelling INO80 complex promotes resolution of R-loops to prevent replication associated DNA damage in cancer cells.
format	article
author	Lisa Prendergast Urszula L. McClurg Rossitsa Hristova Rolando Berlinguer-Palmini Sarah Greener Katie Veitch Inmaculada Hernandez Philippe Pasero Daniel Rico Jonathan M. G. Higgins Anastas Gospodinov Manolis Papamichos-Chronakis
author_facet	Lisa Prendergast Urszula L. McClurg Rossitsa Hristova Rolando Berlinguer-Palmini Sarah Greener Katie Veitch Inmaculada Hernandez Philippe Pasero Daniel Rico Jonathan M. G. Higgins Anastas Gospodinov Manolis Papamichos-Chronakis
author_sort	Lisa Prendergast
title	Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
title_short	Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
title_full	Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
title_fullStr	Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
title_full_unstemmed	Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
title_sort	resolution of r-loops by ino80 promotes dna replication and maintains cancer cell proliferation and viability
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0
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Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability

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