Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability

Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability

In mammalian cells, during transcription and replication, RNA:DNA hybrid structures known as R-loops can arise, posing as obstacles to replication fork progression. Here the authors reveal that the ATP-dependent chromatin remodelling INO80 complex promotes resolution of R-loops to prevent replicatio...

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Bibliographic Details
Main Authors: Lisa Prendergast, Urszula L. McClurg, Rossitsa Hristova, Rolando Berlinguer-Palmini, Sarah Greener, Katie Veitch, Inmaculada Hernandez, Philippe Pasero, Daniel Rico, Jonathan M. G. Higgins, Anastas Gospodinov, Manolis Papamichos-Chronakis
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0
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https://doaj.org/article/dcd1345330a848728d9de1a0310ef7f0

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