Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area

Jing Zhao,1,2,&ast; Yinbiao Su,3,&ast; Jin-An Zhang,2 Ming Fang,4 Xuerong Liu,2 Xi Jia,2 Xinming Li1,4 1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Department of Endocrinology, Shanghai University of Medicine & Heal...

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Autores principales:	Zhao J, Su Y, Zhang JA, Fang M, Liu X, Jia X, Li X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	dyslipidemia hypertension hyperglycemia abdominal obesity Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/dcd39da274ce4d1cb14f3f7c19f6923e
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spelling	oai:doaj.org-article:dcd39da274ce4d1cb14f3f7c19f6923e2021-12-02T17:08:57ZInverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area1178-7007https://doaj.org/article/dcd39da274ce4d1cb14f3f7c19f6923e2021-08-01T00:00:00Zhttps://www.dovepress.com/inverse-association-between-iodine-status-and-prevalence-of-metabolic--peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Jing Zhao,1,2,&ast; Yinbiao Su,3,&ast; Jin-An Zhang,2 Ming Fang,4 Xuerong Liu,2 Xi Jia,2 Xinming Li1,4 1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of China; 3Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, 201508, People’s Republic of China; 4Department of Cardiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xinming LiGraduate School, Shanghai University of Traditional Chinese Medicine, Department of Cardiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of ChinaTel +86 21-68135590-3160Email XinmingLi-SH@hotmail.comPurpose: To investigate the relationship between iodine intake status and the prevalence of metabolic syndrome (MetS) through a population-based survey.Patients and Methods: In total, 2691 Chinese adults participated in this cross-sectional study, and they were stratified by urinary iodine concentration (UIC) and sex. Fasting blood samples were used to assess biochemical parameters, including thyroid function and antibodies. Urine samples were collected in the morning to measure UIC. Multivariate regression logistic analysis was performed for the overall population and sex subgroups.Results: An inverse association was observed between iodine intake status and MetS prevalence in Chinese adults. Compared with individuals with adequate iodine status, those with high-iodine status had significantly low MetS risks, and the adjusted odds ratios (95% confidence interval) were 0.70 (0.57– 0.86, P < 0.01) and 0.75 (0.6– 0.95, P < 0.05). A high MetS risk was observed in the iodine-deficient group, which did not reach statistical significance. There was a significant inverse linear trend between the risk of MetS and UIC in the total population and male subgroup (P for trend < 0.05), which was not observed in the female subgroup (P for trend > 0.05).Conclusion: An inverse association was observed between iodine intake status and the risk of developing MetS in Chinese adults. Sufficient iodine status is a potential protective factor for MetS development. Males may benefit from increased iodine intake, while females would need to achieve a more-than-adequate iodine status to gain metabolic benefits.Keywords: dyslipidemia, hypertension, hyperglycemia, abdominal obesityZhao JSu YZhang JAFang MLiu XJia XLi XDove Medical Pressarticledyslipidemiahypertensionhyperglycemiaabdominal obesitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3691-3701 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dyslipidemia hypertension hyperglycemia abdominal obesity Specialties of internal medicine RC581-951
spellingShingle	dyslipidemia hypertension hyperglycemia abdominal obesity Specialties of internal medicine RC581-951 Zhao J Su Y Zhang JA Fang M Liu X Jia X Li X Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area
description	Jing Zhao,1,2,&ast; Yinbiao Su,3,&ast; Jin-An Zhang,2 Ming Fang,4 Xuerong Liu,2 Xi Jia,2 Xinming Li1,4 1Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of China; 3Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, 201508, People’s Republic of China; 4Department of Cardiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xinming LiGraduate School, Shanghai University of Traditional Chinese Medicine, Department of Cardiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of ChinaTel +86 21-68135590-3160Email XinmingLi-SH@hotmail.comPurpose: To investigate the relationship between iodine intake status and the prevalence of metabolic syndrome (MetS) through a population-based survey.Patients and Methods: In total, 2691 Chinese adults participated in this cross-sectional study, and they were stratified by urinary iodine concentration (UIC) and sex. Fasting blood samples were used to assess biochemical parameters, including thyroid function and antibodies. Urine samples were collected in the morning to measure UIC. Multivariate regression logistic analysis was performed for the overall population and sex subgroups.Results: An inverse association was observed between iodine intake status and MetS prevalence in Chinese adults. Compared with individuals with adequate iodine status, those with high-iodine status had significantly low MetS risks, and the adjusted odds ratios (95% confidence interval) were 0.70 (0.57– 0.86, P < 0.01) and 0.75 (0.6– 0.95, P < 0.05). A high MetS risk was observed in the iodine-deficient group, which did not reach statistical significance. There was a significant inverse linear trend between the risk of MetS and UIC in the total population and male subgroup (P for trend < 0.05), which was not observed in the female subgroup (P for trend > 0.05).Conclusion: An inverse association was observed between iodine intake status and the risk of developing MetS in Chinese adults. Sufficient iodine status is a potential protective factor for MetS development. Males may benefit from increased iodine intake, while females would need to achieve a more-than-adequate iodine status to gain metabolic benefits.Keywords: dyslipidemia, hypertension, hyperglycemia, abdominal obesity
format	article
author	Zhao J Su Y Zhang JA Fang M Liu X Jia X Li X
author_facet	Zhao J Su Y Zhang JA Fang M Liu X Jia X Li X
author_sort	Zhao J
title	Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area
title_short	Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area
title_full	Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area
title_fullStr	Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area
title_full_unstemmed	Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area
title_sort	inverse association between iodine status and prevalence of metabolic syndrome: a cross-sectional population-based study in a chinese moderate iodine intake area
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/dcd39da274ce4d1cb14f3f7c19f6923e
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Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area

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