Ozonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability

Amoxicillin (AMX) and Ciprofloxacin (CIP) are antibiotics commonly used in human medicine with high environmental toxicity and poor biodegradability. They have been found in various hospital effluents and groundwater, and their environmental impact is still not fully understood. In this work, we inv...

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Autores principales:	Severina Aleksić, Andreja Žgajnar Gotvajn, Katarina Premzl, Mitja Kolar, Sonja Šostar Turk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	amoxicillin (AMX) antibiotic ciprofloxacin (CIP) hospital wastewater hydrogen peroxide ozone Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/dcd595a984c04fe1853b690419fb073f
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spelling	oai:doaj.org-article:dcd595a984c04fe1853b690419fb073f2021-11-25T16:24:54ZOzonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability10.3390/antibiotics101114072079-6382https://doaj.org/article/dcd595a984c04fe1853b690419fb073f2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1407https://doaj.org/toc/2079-6382Amoxicillin (AMX) and Ciprofloxacin (CIP) are antibiotics commonly used in human medicine with high environmental toxicity and poor biodegradability. They have been found in various hospital effluents and groundwater, and their environmental impact is still not fully understood. In this work, we investigated the possibility of treating model wastewaters containing the antibiotics AMX and CIP using ozonation, with the addition of H<sub>2</sub>O<sub>2</sub> under various conditions, including different pH values, H<sub>2</sub>O<sub>2</sub>, and ozone dosages. The quantification of and treatment efficacy for antibiotic removal were determined via solid phase extraction followed by chromatographic separation by liquid chromatography coupled with tandem triple quadrupole mass spectrometry (LC/MS/MS). This analytical system is quite efficient for the detection of all major antibiotic classes, even if they are present at very low concentrations. The efficiency of ozonation was determined by measuring the TOC (Total Organic Carbon) changes after ozonation of the model wastewater and by measuring the concentration of the two antibiotics. In a sequential activated sludge process of ozone-treated model wastewater, almost complete TOC removal and an overwhelming decrease in antibiotic concentrations (up to 99%) were observed. Ozonation resulted in complete removal of AMX and CIP in less than 30 and 120 min, respectively. The results of this work indicate that ozonation could be a suitable pretreatment method to reduce the toxicity of contaminants (AMX and CIP) and improve the biodegradability of hospital wastewater.Severina AleksićAndreja Žgajnar GotvajnKatarina PremzlMitja KolarSonja Šostar TurkMDPI AGarticleamoxicillin (AMX)antibioticciprofloxacin (CIP)hospital wastewaterhydrogen peroxideozoneTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1407, p 1407 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amoxicillin (AMX) antibiotic ciprofloxacin (CIP) hospital wastewater hydrogen peroxide ozone Therapeutics. Pharmacology RM1-950
spellingShingle	amoxicillin (AMX) antibiotic ciprofloxacin (CIP) hospital wastewater hydrogen peroxide ozone Therapeutics. Pharmacology RM1-950 Severina Aleksić Andreja Žgajnar Gotvajn Katarina Premzl Mitja Kolar Sonja Šostar Turk Ozonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability
description	Amoxicillin (AMX) and Ciprofloxacin (CIP) are antibiotics commonly used in human medicine with high environmental toxicity and poor biodegradability. They have been found in various hospital effluents and groundwater, and their environmental impact is still not fully understood. In this work, we investigated the possibility of treating model wastewaters containing the antibiotics AMX and CIP using ozonation, with the addition of H<sub>2</sub>O<sub>2</sub> under various conditions, including different pH values, H<sub>2</sub>O<sub>2</sub>, and ozone dosages. The quantification of and treatment efficacy for antibiotic removal were determined via solid phase extraction followed by chromatographic separation by liquid chromatography coupled with tandem triple quadrupole mass spectrometry (LC/MS/MS). This analytical system is quite efficient for the detection of all major antibiotic classes, even if they are present at very low concentrations. The efficiency of ozonation was determined by measuring the TOC (Total Organic Carbon) changes after ozonation of the model wastewater and by measuring the concentration of the two antibiotics. In a sequential activated sludge process of ozone-treated model wastewater, almost complete TOC removal and an overwhelming decrease in antibiotic concentrations (up to 99%) were observed. Ozonation resulted in complete removal of AMX and CIP in less than 30 and 120 min, respectively. The results of this work indicate that ozonation could be a suitable pretreatment method to reduce the toxicity of contaminants (AMX and CIP) and improve the biodegradability of hospital wastewater.
format	article
author	Severina Aleksić Andreja Žgajnar Gotvajn Katarina Premzl Mitja Kolar Sonja Šostar Turk
author_facet	Severina Aleksić Andreja Žgajnar Gotvajn Katarina Premzl Mitja Kolar Sonja Šostar Turk
author_sort	Severina Aleksić
title	Ozonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability
title_short	Ozonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability
title_full	Ozonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability
title_fullStr	Ozonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability
title_full_unstemmed	Ozonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability
title_sort	ozonation of amoxicillin and ciprofloxacin in model hospital wastewater to increase biotreatability
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dcd595a984c04fe1853b690419fb073f
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_version_	1718413230915715072

Ozonation of Amoxicillin and Ciprofloxacin in Model Hospital Wastewater to Increase Biotreatability

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