Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants

Lijie Zhang1, Yupeng Chen2, Jose Rodriguez3, Hicham Fenniri3, Thomas J Webster11Division of Engineering, 2Department of Chemistry, Brown University, Providence, RI, USA; 3National Institute for Nanotechnology and Department of Chemistry, University of Alberta, Edmonton, AB, CanadaAbstract: Natural b...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lijie Zhang, Yupeng Chen, Jose Rodriguez, Hicham Fenniri, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dcd70b91b71f452bb5b9a47aa15b7a12
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dcd70b91b71f452bb5b9a47aa15b7a12
record_format	dspace
spelling	oai:doaj.org-article:dcd70b91b71f452bb5b9a47aa15b7a122021-12-02T02:35:14ZBiomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants1176-91141178-2013https://doaj.org/article/dcd70b91b71f452bb5b9a47aa15b7a122008-10-01T00:00:00Zhttp://www.dovepress.com/biomimetic-helical-rosette-nanotubes-and-nanocrystalline-hydroxyapatit-a2431https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Lijie Zhang1, Yupeng Chen2, Jose Rodriguez3, Hicham Fenniri3, Thomas J Webster11Division of Engineering, 2Department of Chemistry, Brown University, Providence, RI, USA; 3National Institute for Nanotechnology and Department of Chemistry, University of Alberta, Edmonton, AB, CanadaAbstract: Natural bone consists of hard nanostructured hydroxyapatite (HA) in a nanostructured protein-based soft hydrogel template (ie, mostly collagen). For this reason, nanostructured HA has been an intriguing coating material on traditionally used titanium for improving orthopedic applications. In addition, helical rosette nanotubes (HRNs), newly developed materials which form through the self-assembly process of DNA base pair building blocks in body solutions, are soft nanotubes with a helical architecture that mimics natural collagen. Thus, the objective of this in vitro study was for the first time to combine the promising attributes of HRNs and nanocrystalline HA on titanium and assess osteoblast (bone-forming cell) functions. Different sizes of nanocrystalline HA were synthesized in this study through a wet chemical precipitation process following either hydrothermal treatment or sintering. Transmission electron microscopy images showed that HRNs aligned with nanocrystalline HA, which indicates a high affinity between both components. Some of the nanocrystalline HA formed dense coatings with HRNs on titanium. More importantly, results demonstrated enhanced osteoblast adhesion on the HRN/nanocrystalline HA-coated titanium compared with conventional uncoated titanium. Among all the HRN/nanocrystalline HA coatings tested, osteoblast adhesion was the greatest when HA nanometer particle size was the smallest. In this manner, this study demonstrated for the first time that biomimetic HRN/nanocrystalline HA coatings on titanium were cytocompatible for osteoblasts and, thus, should be further studied for improving orthopedic implants.Keywords: helical rosette nanotubes, nanocrystalline hydroxyapatite, biomimetic, titanium, osteoblast, self assembled Lijie ZhangYupeng ChenJose RodriguezHicham FenniriThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 3, Pp 323-333 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lijie Zhang Yupeng Chen Jose Rodriguez Hicham Fenniri Thomas J Webster Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
description	Lijie Zhang1, Yupeng Chen2, Jose Rodriguez3, Hicham Fenniri3, Thomas J Webster11Division of Engineering, 2Department of Chemistry, Brown University, Providence, RI, USA; 3National Institute for Nanotechnology and Department of Chemistry, University of Alberta, Edmonton, AB, CanadaAbstract: Natural bone consists of hard nanostructured hydroxyapatite (HA) in a nanostructured protein-based soft hydrogel template (ie, mostly collagen). For this reason, nanostructured HA has been an intriguing coating material on traditionally used titanium for improving orthopedic applications. In addition, helical rosette nanotubes (HRNs), newly developed materials which form through the self-assembly process of DNA base pair building blocks in body solutions, are soft nanotubes with a helical architecture that mimics natural collagen. Thus, the objective of this in vitro study was for the first time to combine the promising attributes of HRNs and nanocrystalline HA on titanium and assess osteoblast (bone-forming cell) functions. Different sizes of nanocrystalline HA were synthesized in this study through a wet chemical precipitation process following either hydrothermal treatment or sintering. Transmission electron microscopy images showed that HRNs aligned with nanocrystalline HA, which indicates a high affinity between both components. Some of the nanocrystalline HA formed dense coatings with HRNs on titanium. More importantly, results demonstrated enhanced osteoblast adhesion on the HRN/nanocrystalline HA-coated titanium compared with conventional uncoated titanium. Among all the HRN/nanocrystalline HA coatings tested, osteoblast adhesion was the greatest when HA nanometer particle size was the smallest. In this manner, this study demonstrated for the first time that biomimetic HRN/nanocrystalline HA coatings on titanium were cytocompatible for osteoblasts and, thus, should be further studied for improving orthopedic implants.Keywords: helical rosette nanotubes, nanocrystalline hydroxyapatite, biomimetic, titanium, osteoblast, self assembled
format	article
author	Lijie Zhang Yupeng Chen Jose Rodriguez Hicham Fenniri Thomas J Webster
author_facet	Lijie Zhang Yupeng Chen Jose Rodriguez Hicham Fenniri Thomas J Webster
author_sort	Lijie Zhang
title	Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
title_short	Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
title_full	Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
title_fullStr	Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
title_full_unstemmed	Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
title_sort	biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/dcd70b91b71f452bb5b9a47aa15b7a12
work_keys_str_mv	AT lijiezhang biomimetichelicalrosettenanotubesandnanocrystallinehydroxyapatitecoatingsontitaniumforimprovingorthopedicimplants AT yupengchen biomimetichelicalrosettenanotubesandnanocrystallinehydroxyapatitecoatingsontitaniumforimprovingorthopedicimplants AT joserodriguez biomimetichelicalrosettenanotubesandnanocrystallinehydroxyapatitecoatingsontitaniumforimprovingorthopedicimplants AT hichamfenniri biomimetichelicalrosettenanotubesandnanocrystallinehydroxyapatitecoatingsontitaniumforimprovingorthopedicimplants AT thomasjwebster biomimetichelicalrosettenanotubesandnanocrystallinehydroxyapatitecoatingsontitaniumforimprovingorthopedicimplants
_version_	1718402380049940480

Biomimetic helical rosette nanotubes and nanocrystalline hydroxyapatite coatings on titanium for improving orthopedic implants

Ejemplares similares