Differentially expressed proteins in malignant and benign adrenocortical tumors.

We have compared the microsomal protein composition of eight malignant and six benign adrenocortical tumors with proteomic methods. IGF2 had increased level in the malignant tumors, confirming previous microarray studies on the same material. Aldolase A, a glycolytic enzyme, also showed increased le...

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Autores principales:	Hanna Kjellin, Henrik Johansson, Anders Höög, Janne Lehtiö, Per-Johan Jakobsson, Magnus Kjellman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcd70e2700914927a91bd149e9e50e30
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spelling	oai:doaj.org-article:dcd70e2700914927a91bd149e9e50e302021-11-18T08:34:07ZDifferentially expressed proteins in malignant and benign adrenocortical tumors.1932-620310.1371/journal.pone.0087951https://doaj.org/article/dcd70e2700914927a91bd149e9e50e302014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498411/?tool=EBIhttps://doaj.org/toc/1932-6203We have compared the microsomal protein composition of eight malignant and six benign adrenocortical tumors with proteomic methods. IGF2 had increased level in the malignant tumors, confirming previous microarray studies on the same material. Aldolase A, a glycolytic enzyme, also showed increased levels in the malignant tissue compared to the benign. Additionally, several proteins belonging to complex I in the mitochondrial respiration chain showed decreased levels in the malignant tissue. Taken together, this may indicate a shift in energy metabolism where glycolysis may be favored over tight coupling of glycolysis and mitochondrial respiration, a phenomenon known as the Warburg effect. One of the complex I proteins that showed decreased levels in the malignant tissue was GRIM-19. This protein has been suggested as a tumor suppressive protein by being a negative regulator of STAT3. In summary, an analysis of the microsomal proteome in adrenocortical tumors identifies groups of proteins as well as specific proteins differentially expressed in the benign and malignant forms. These proteins shed light on the biology behind malignancy and could delineate future drug targets.Hanna KjellinHenrik JohanssonAnders HöögJanne LehtiöPer-Johan JakobssonMagnus KjellmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e87951 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hanna Kjellin Henrik Johansson Anders Höög Janne Lehtiö Per-Johan Jakobsson Magnus Kjellman Differentially expressed proteins in malignant and benign adrenocortical tumors.
description	We have compared the microsomal protein composition of eight malignant and six benign adrenocortical tumors with proteomic methods. IGF2 had increased level in the malignant tumors, confirming previous microarray studies on the same material. Aldolase A, a glycolytic enzyme, also showed increased levels in the malignant tissue compared to the benign. Additionally, several proteins belonging to complex I in the mitochondrial respiration chain showed decreased levels in the malignant tissue. Taken together, this may indicate a shift in energy metabolism where glycolysis may be favored over tight coupling of glycolysis and mitochondrial respiration, a phenomenon known as the Warburg effect. One of the complex I proteins that showed decreased levels in the malignant tissue was GRIM-19. This protein has been suggested as a tumor suppressive protein by being a negative regulator of STAT3. In summary, an analysis of the microsomal proteome in adrenocortical tumors identifies groups of proteins as well as specific proteins differentially expressed in the benign and malignant forms. These proteins shed light on the biology behind malignancy and could delineate future drug targets.
format	article
author	Hanna Kjellin Henrik Johansson Anders Höög Janne Lehtiö Per-Johan Jakobsson Magnus Kjellman
author_facet	Hanna Kjellin Henrik Johansson Anders Höög Janne Lehtiö Per-Johan Jakobsson Magnus Kjellman
author_sort	Hanna Kjellin
title	Differentially expressed proteins in malignant and benign adrenocortical tumors.
title_short	Differentially expressed proteins in malignant and benign adrenocortical tumors.
title_full	Differentially expressed proteins in malignant and benign adrenocortical tumors.
title_fullStr	Differentially expressed proteins in malignant and benign adrenocortical tumors.
title_full_unstemmed	Differentially expressed proteins in malignant and benign adrenocortical tumors.
title_sort	differentially expressed proteins in malignant and benign adrenocortical tumors.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/dcd70e2700914927a91bd149e9e50e30
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_version_	1718421651947782144

Differentially expressed proteins in malignant and benign adrenocortical tumors.

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