Review: brain neurobiology of gambling disorder based on rodent models

Gabriel C Quintero GarzolaFlorida State University – Republic of Panama, Panama City, Republic of PanamaAbstract: Different literature reviews of gambling disorder (GD) neurobiology have been focused on human studies, others have focused on rodents, and others combined human and rodent stu...

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Autor principal:	Quintero Garzola GC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	gambling disorder review nervous system murine paradigm. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/dcd80214bc7346d4ac0f81b54db1c43b
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spelling	oai:doaj.org-article:dcd80214bc7346d4ac0f81b54db1c43b2021-12-02T00:44:31ZReview: brain neurobiology of gambling disorder based on rodent models1178-2021https://doaj.org/article/dcd80214bc7346d4ac0f81b54db1c43b2019-07-01T00:00:00Zhttps://www.dovepress.com/review-brain-neurobiology-of-gambling-disorder-based-on-rodent-models-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Gabriel C Quintero GarzolaFlorida State University – Republic of Panama, Panama City, Republic of PanamaAbstract: Different literature reviews of gambling disorder (GD) neurobiology have been focused on human studies, others have focused on rodents, and others combined human and rodent studies. The main question of this review was: which are the main neurotransmitters systems and brain structures relevant for GD based on recent rodent studies? This work aims to review the experimental findings regarding the rodent´s neurobiology of GD. A search in the Pub Med database was set (October 2012–October 2017) and 162 references were obtained. After screening, 121 references were excluded, and only 41 references remained from the initial output. More, other 25 references were added to complement (introduction section, neuroanatomical descriptions) the principal part of the work. At the end, a total of 66 references remained for the review. The main conclusions are: 1) according to studies that used noninvasive methods for drug administration, some of the neurotransmitters and receptors involved in behaviors related to GD are: muscarinic, N-methyl-D-aspartate (NMDA), cannabinoid receptor 1 (CB1), cannabinoid receptor 2 (CB2), dopamine 2 receptor (D2), dopamine 3 receptor (D3), and dopamine 4 receptor (D4); 2) moreover, there are other neurotransmitters and receptors involved in GD based on studies that use invasive methods of drug administration (eg, brain microinjection); example of these are: serotonin 1A receptor (5-HT1A), noradrenaline receptors, gamma-aminobutyric acid receptor A (GABAA), and gamma-aminobutyric acid receptor B (GABAB); 3) different brain structures are relevant to behaviors linked to GD, like: amygdala (including basolateral amygdala (BLA)), anterior cingulate cortex (ACC), hippocampus, infralimbic area, insular cortex (anterior and rostral agranular), nucleus accumbens (NAc), olfactory tubercle (island of Calleja), orbitofrontal cortex (OFC), medial prefrontal cortex (mPFC), prefrontal cortex (PFC) – subcortical network, striatum (ventral) and the subthalamic nucleus (STN); and 4) the search for GD treatments should consider this diversity of receptor/neurotransmitter systems and brain areas.Keywords: gambling disorder, review, nervous system, murine paradigmQuintero Garzola GCDove Medical Pressarticlegambling disorderreviewnervous systemmurine paradigm.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1751-1770 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	gambling disorder review nervous system murine paradigm. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	gambling disorder review nervous system murine paradigm. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Quintero Garzola GC Review: brain neurobiology of gambling disorder based on rodent models
description	Gabriel C Quintero GarzolaFlorida State University – Republic of Panama, Panama City, Republic of PanamaAbstract: Different literature reviews of gambling disorder (GD) neurobiology have been focused on human studies, others have focused on rodents, and others combined human and rodent studies. The main question of this review was: which are the main neurotransmitters systems and brain structures relevant for GD based on recent rodent studies? This work aims to review the experimental findings regarding the rodent´s neurobiology of GD. A search in the Pub Med database was set (October 2012–October 2017) and 162 references were obtained. After screening, 121 references were excluded, and only 41 references remained from the initial output. More, other 25 references were added to complement (introduction section, neuroanatomical descriptions) the principal part of the work. At the end, a total of 66 references remained for the review. The main conclusions are: 1) according to studies that used noninvasive methods for drug administration, some of the neurotransmitters and receptors involved in behaviors related to GD are: muscarinic, N-methyl-D-aspartate (NMDA), cannabinoid receptor 1 (CB1), cannabinoid receptor 2 (CB2), dopamine 2 receptor (D2), dopamine 3 receptor (D3), and dopamine 4 receptor (D4); 2) moreover, there are other neurotransmitters and receptors involved in GD based on studies that use invasive methods of drug administration (eg, brain microinjection); example of these are: serotonin 1A receptor (5-HT1A), noradrenaline receptors, gamma-aminobutyric acid receptor A (GABAA), and gamma-aminobutyric acid receptor B (GABAB); 3) different brain structures are relevant to behaviors linked to GD, like: amygdala (including basolateral amygdala (BLA)), anterior cingulate cortex (ACC), hippocampus, infralimbic area, insular cortex (anterior and rostral agranular), nucleus accumbens (NAc), olfactory tubercle (island of Calleja), orbitofrontal cortex (OFC), medial prefrontal cortex (mPFC), prefrontal cortex (PFC) – subcortical network, striatum (ventral) and the subthalamic nucleus (STN); and 4) the search for GD treatments should consider this diversity of receptor/neurotransmitter systems and brain areas.Keywords: gambling disorder, review, nervous system, murine paradigm
format	article
author	Quintero Garzola GC
author_facet	Quintero Garzola GC
author_sort	Quintero Garzola GC
title	Review: brain neurobiology of gambling disorder based on rodent models
title_short	Review: brain neurobiology of gambling disorder based on rodent models
title_full	Review: brain neurobiology of gambling disorder based on rodent models
title_fullStr	Review: brain neurobiology of gambling disorder based on rodent models
title_full_unstemmed	Review: brain neurobiology of gambling disorder based on rodent models
title_sort	review: brain neurobiology of gambling disorder based on rodent models
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/dcd80214bc7346d4ac0f81b54db1c43b
work_keys_str_mv	AT quinterogarzolagc reviewbrainneurobiologyofgamblingdisorderbasedonrodentmodels
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Review: brain neurobiology of gambling disorder based on rodent models

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