Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study
BackgroundThis study aimed to explore the association between serum amino acids (AAs) levels and bone mineral density (BMD).MethodsWe performed a two-sample Mendelian randomization (MR) analysis to analyze the associations between the levels of eight AAs and BMD values by using summary-level genome-...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:dcda5fb6667b416c9085308fe3bbb36d2021-11-09T06:30:38ZRelationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study1664-239210.3389/fendo.2021.763538https://doaj.org/article/dcda5fb6667b416c9085308fe3bbb36d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.763538/fullhttps://doaj.org/toc/1664-2392BackgroundThis study aimed to explore the association between serum amino acids (AAs) levels and bone mineral density (BMD).MethodsWe performed a two-sample Mendelian randomization (MR) analysis to analyze the associations between the levels of eight AAs and BMD values by using summary-level genome-wide association study (GWAS) data. We applied the MR Steiger filtering method and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to check for and remove single nucleotide polymorphisms (SNPs) that were horizontally pleiotropic. The associations were estimated with the inverse variance weighted (IVW), MR-Egger, weighted median and MR Robust Adjusted Profile Score (MR.RAPS) methods.ResultsOur study found that genetically increased isoleucine (Ile) [IVW: effect = 0.1601, 95% confidence interval (CI) = 0.0604 ~ 0.2597, p = 0.0016] and valine (Val) levels (IVW: effect = 0.0953, 95% CI = 0.0251 ~ 0.1655, p = 0.0078) were positively associated with total body BMD (TB-BMD). The results also revealed that genetically increased tyrosine (Tyr) levels were negatively associated with TB-BMD (IVW: effect = -0.1091, 95% CI = -0.1863 ~ -0.0320, p = 0.0055).ConclusionsIn this study, associations between serum AA levels and BMD were established. These findings underscore the important role that serum AAs play in the development of osteoporosis and provide evidence that osteoporosis can be prevented and treated by the intake of certain AAs.Zhiyong CuiZhiyong CuiZhiyong CuiHui FengHui FengHui FengBaichuan HeBaichuan HeBaichuan HeJinyao HeJinyao HeJinyao HeYun TianYun TianYun TianFrontiers Media S.A.articleamino acidbone mineral density – BMDMendelian randomizationvalinetyrosineisoleucineDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
amino acid bone mineral density – BMD Mendelian randomization valine tyrosine isoleucine Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
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amino acid bone mineral density – BMD Mendelian randomization valine tyrosine isoleucine Diseases of the endocrine glands. Clinical endocrinology RC648-665 Zhiyong Cui Zhiyong Cui Zhiyong Cui Hui Feng Hui Feng Hui Feng Baichuan He Baichuan He Baichuan He Jinyao He Jinyao He Jinyao He Yun Tian Yun Tian Yun Tian Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study |
| description |
BackgroundThis study aimed to explore the association between serum amino acids (AAs) levels and bone mineral density (BMD).MethodsWe performed a two-sample Mendelian randomization (MR) analysis to analyze the associations between the levels of eight AAs and BMD values by using summary-level genome-wide association study (GWAS) data. We applied the MR Steiger filtering method and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to check for and remove single nucleotide polymorphisms (SNPs) that were horizontally pleiotropic. The associations were estimated with the inverse variance weighted (IVW), MR-Egger, weighted median and MR Robust Adjusted Profile Score (MR.RAPS) methods.ResultsOur study found that genetically increased isoleucine (Ile) [IVW: effect = 0.1601, 95% confidence interval (CI) = 0.0604 ~ 0.2597, p = 0.0016] and valine (Val) levels (IVW: effect = 0.0953, 95% CI = 0.0251 ~ 0.1655, p = 0.0078) were positively associated with total body BMD (TB-BMD). The results also revealed that genetically increased tyrosine (Tyr) levels were negatively associated with TB-BMD (IVW: effect = -0.1091, 95% CI = -0.1863 ~ -0.0320, p = 0.0055).ConclusionsIn this study, associations between serum AA levels and BMD were established. These findings underscore the important role that serum AAs play in the development of osteoporosis and provide evidence that osteoporosis can be prevented and treated by the intake of certain AAs. |
| format |
article |
| author |
Zhiyong Cui Zhiyong Cui Zhiyong Cui Hui Feng Hui Feng Hui Feng Baichuan He Baichuan He Baichuan He Jinyao He Jinyao He Jinyao He Yun Tian Yun Tian Yun Tian |
| author_facet |
Zhiyong Cui Zhiyong Cui Zhiyong Cui Hui Feng Hui Feng Hui Feng Baichuan He Baichuan He Baichuan He Jinyao He Jinyao He Jinyao He Yun Tian Yun Tian Yun Tian |
| author_sort |
Zhiyong Cui |
| title |
Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study |
| title_short |
Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study |
| title_full |
Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study |
| title_fullStr |
Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study |
| title_full_unstemmed |
Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study |
| title_sort |
relationship between serum amino acid levels and bone mineral density: a mendelian randomization study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/dcda5fb6667b416c9085308fe3bbb36d |
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