Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.

<h4>Objective and design</h4>The soluble urokinase plasminogen activator receptor (suPAR) has been recently recognized as a potential biological marker of various disease states, but the impact of a major surgical intervention on the suPAR level has not yet been established. The aim of o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Waldemar Gozdzik, Barbara Adamik, Anna Gozdzik, Maciej Rachwalik, Wojciech Kustrzycki, Andrzej Kübler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcdc308be3ac4f7eac6661b36689fd9e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dcdc308be3ac4f7eac6661b36689fd9e
record_format	dspace
spelling	oai:doaj.org-article:dcdc308be3ac4f7eac6661b36689fd9e2021-11-18T08:16:32ZUnchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.1932-620310.1371/journal.pone.0098923https://doaj.org/article/dcdc308be3ac4f7eac6661b36689fd9e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24911522/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective and design</h4>The soluble urokinase plasminogen activator receptor (suPAR) has been recently recognized as a potential biological marker of various disease states, but the impact of a major surgical intervention on the suPAR level has not yet been established. The aim of our study was to investigate if the induction of a systemic inflammatory reaction in response to cardiopulmonary bypass would be accompanied by an increase in the plasma suPAR level.<h4>Methods and subjects</h4>Patients undergoing coronary artery bypass grafting under cardiopulmonary bypass (CPB) were added. Based on the baseline suPAR level, patients were divided into group 1 (suPAR within normal range) or group 2 (suPAR above range). Blood was collected before the induction of anesthesia and 6 and 24 hours after surgery. Plasma suPAR, IL-6, IL-8, TNF-α, troponin I, NT-proBNP, and NGAL were quantified to assess the impact of surgical trauma on these markers.<h4>Results</h4>The baseline suPAR level was within the normal range in 31 patients (3.3 ng/mL), and elevated in 29 (5.1 ng/mL) (p<0.001). Baseline mediators of systemic inflammatory reaction concentrations (IL-6, TNF-α, and IL-8) and organ injury indices (troponin I, NT-proBNP, and NGAL) were low and increased after surgery in all patients (p<0.05). The surgery did not cause significant changes in the suPAR level either at 6 or 24 hours after, however the difference between groups observed at baseline remained substantial during the postoperative period.<h4>Conclusions</h4>There was no change in the suPAR level observed in patients subjected to elective cardiac coronary artery bypass surgery and CPB, despite activation of a systemic inflammatory reaction.Waldemar GozdzikBarbara AdamikAnna GozdzikMaciej RachwalikWojciech KustrzyckiAndrzej KüblerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98923 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Waldemar Gozdzik Barbara Adamik Anna Gozdzik Maciej Rachwalik Wojciech Kustrzycki Andrzej Kübler Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.
description	<h4>Objective and design</h4>The soluble urokinase plasminogen activator receptor (suPAR) has been recently recognized as a potential biological marker of various disease states, but the impact of a major surgical intervention on the suPAR level has not yet been established. The aim of our study was to investigate if the induction of a systemic inflammatory reaction in response to cardiopulmonary bypass would be accompanied by an increase in the plasma suPAR level.<h4>Methods and subjects</h4>Patients undergoing coronary artery bypass grafting under cardiopulmonary bypass (CPB) were added. Based on the baseline suPAR level, patients were divided into group 1 (suPAR within normal range) or group 2 (suPAR above range). Blood was collected before the induction of anesthesia and 6 and 24 hours after surgery. Plasma suPAR, IL-6, IL-8, TNF-α, troponin I, NT-proBNP, and NGAL were quantified to assess the impact of surgical trauma on these markers.<h4>Results</h4>The baseline suPAR level was within the normal range in 31 patients (3.3 ng/mL), and elevated in 29 (5.1 ng/mL) (p<0.001). Baseline mediators of systemic inflammatory reaction concentrations (IL-6, TNF-α, and IL-8) and organ injury indices (troponin I, NT-proBNP, and NGAL) were low and increased after surgery in all patients (p<0.05). The surgery did not cause significant changes in the suPAR level either at 6 or 24 hours after, however the difference between groups observed at baseline remained substantial during the postoperative period.<h4>Conclusions</h4>There was no change in the suPAR level observed in patients subjected to elective cardiac coronary artery bypass surgery and CPB, despite activation of a systemic inflammatory reaction.
format	article
author	Waldemar Gozdzik Barbara Adamik Anna Gozdzik Maciej Rachwalik Wojciech Kustrzycki Andrzej Kübler
author_facet	Waldemar Gozdzik Barbara Adamik Anna Gozdzik Maciej Rachwalik Wojciech Kustrzycki Andrzej Kübler
author_sort	Waldemar Gozdzik
title	Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.
title_short	Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.
title_full	Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.
title_fullStr	Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.
title_full_unstemmed	Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.
title_sort	unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/dcdc308be3ac4f7eac6661b36689fd9e
work_keys_str_mv	AT waldemargozdzik unchangedplasmalevelsofthesolubleurokinaseplasminogenactivatorreceptorinelectivecoronaryarterybypassgraftsurgerypatientsandcardiopulmonarybypassuse AT barbaraadamik unchangedplasmalevelsofthesolubleurokinaseplasminogenactivatorreceptorinelectivecoronaryarterybypassgraftsurgerypatientsandcardiopulmonarybypassuse AT annagozdzik unchangedplasmalevelsofthesolubleurokinaseplasminogenactivatorreceptorinelectivecoronaryarterybypassgraftsurgerypatientsandcardiopulmonarybypassuse AT maciejrachwalik unchangedplasmalevelsofthesolubleurokinaseplasminogenactivatorreceptorinelectivecoronaryarterybypassgraftsurgerypatientsandcardiopulmonarybypassuse AT wojciechkustrzycki unchangedplasmalevelsofthesolubleurokinaseplasminogenactivatorreceptorinelectivecoronaryarterybypassgraftsurgerypatientsandcardiopulmonarybypassuse AT andrzejkubler unchangedplasmalevelsofthesolubleurokinaseplasminogenactivatorreceptorinelectivecoronaryarterybypassgraftsurgerypatientsandcardiopulmonarybypassuse
_version_	1718422016426508288

Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use.

Ejemplares similares