Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma

Qunying Han,1 Huan Deng,1 Xiude Fan,1 Xiaoyun Wang,1 Xiaoge Zhang,1 Kun Zhang,1 Na Li,1 Yi Lv,2,3 Zhengwen Liu1,3 1Department of Infectious Diseases, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Hepatobiliary Surgery, First Affili...

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Autores principales:	Han Q, Deng H, Fan X, Wang X, Zhang X, Zhang K, Li N, Lv Y, Liu Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hepatocellular carcinoma pentraxin 3 chronic hbv infection survival prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/dcdcb415d6d745c0aff29aa25324c745
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spelling	oai:doaj.org-article:dcdcb415d6d745c0aff29aa25324c7452021-11-14T19:00:30ZIncreased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma2253-5969https://doaj.org/article/dcdcb415d6d745c0aff29aa25324c7452021-11-01T00:00:00Zhttps://www.dovepress.com/increased-serum-pentraxin-3-levels-are-associated-with-poor-prognosis--peer-reviewed-fulltext-article-JHChttps://doaj.org/toc/2253-5969Qunying Han,1 Huan Deng,1 Xiude Fan,1 Xiaoyun Wang,1 Xiaoge Zhang,1 Kun Zhang,1 Na Li,1 Yi Lv,2,3 Zhengwen Liu1,3 1Department of Infectious Diseases, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Institute of Advanced Surgical Technology and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Zhengwen LiuDepartment of Infectious Diseases, First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an, 710061, Shaanxi Province, People’s Republic of ChinaEmail liuzhengwen113@xjtu.edu.cnBackground: Hepatocellular carcinoma (HCC) is a major cause of liver-related mortality. Serum pentraxin 3 (PTX3) has been revealed to be associated with the development of hepatitis B virus (HBV)-related HCC. This study evaluated whether serum PTX3 is related to the survival of HBV-related HCC patients.Methods: One hundred and seven patients with HBV-related HCC were included. Baseline serum PTX3 levels were quantified using quantitative immunoassay. The HCC patients were followed-up for a median of 24 months and divided into high serum PTX3 level and low PTX3 level groups according to the baseline serum PTX3 levels. The overall survivals of the HBV-related HCC patients according to the serum PTX3 levels were compared. Factors potentially influencing the prognosis of the patients with HBV-related HCC were analyzed.Results: HCC patients with high serum PTX3 levels [PTX3 > 9.25ng/mL (n=85)] had a shorter overall survival time than HCC patients with low serum PTX3 levels [PTX3 ≤ 9.25ng/mL (n=22)] (P = 0.049). HCC patients with serum PTX3 levels between > 9.25ng/mL and ≤ 9.25ng/mL had significant difference in HCC histology grade. Multivariate analysis showed that PTX3 level was an independent risk factor related to the overall survival of HCC patients (hazard ratio: 1.058, 95% confidence interval: 1.031– 1.085, P < 0.001).Conclusion: These results support the involvement of PTX3 in the disease progression of HCC and suggest the potential of using serum PTX3 levels as a biomarker for the prognostic prediction of HBV-related HCC patients.Keywords: hepatocellular carcinoma, pentraxin 3, chronic HBV infection, survival, prognosisHan QDeng HFan XWang XZhang XZhang KLi NLv YLiu ZDove Medical Pressarticlehepatocellular carcinomapentraxin 3chronic hbv infectionsurvivalprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Hepatocellular Carcinoma, Vol Volume 8, Pp 1367-1373 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma pentraxin 3 chronic hbv infection survival prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma pentraxin 3 chronic hbv infection survival prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Han Q Deng H Fan X Wang X Zhang X Zhang K Li N Lv Y Liu Z Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma
description	Qunying Han,1 Huan Deng,1 Xiude Fan,1 Xiaoyun Wang,1 Xiaoge Zhang,1 Kun Zhang,1 Na Li,1 Yi Lv,2,3 Zhengwen Liu1,3 1Department of Infectious Diseases, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Institute of Advanced Surgical Technology and Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Zhengwen LiuDepartment of Infectious Diseases, First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an, 710061, Shaanxi Province, People’s Republic of ChinaEmail liuzhengwen113@xjtu.edu.cnBackground: Hepatocellular carcinoma (HCC) is a major cause of liver-related mortality. Serum pentraxin 3 (PTX3) has been revealed to be associated with the development of hepatitis B virus (HBV)-related HCC. This study evaluated whether serum PTX3 is related to the survival of HBV-related HCC patients.Methods: One hundred and seven patients with HBV-related HCC were included. Baseline serum PTX3 levels were quantified using quantitative immunoassay. The HCC patients were followed-up for a median of 24 months and divided into high serum PTX3 level and low PTX3 level groups according to the baseline serum PTX3 levels. The overall survivals of the HBV-related HCC patients according to the serum PTX3 levels were compared. Factors potentially influencing the prognosis of the patients with HBV-related HCC were analyzed.Results: HCC patients with high serum PTX3 levels [PTX3 > 9.25ng/mL (n=85)] had a shorter overall survival time than HCC patients with low serum PTX3 levels [PTX3 ≤ 9.25ng/mL (n=22)] (P = 0.049). HCC patients with serum PTX3 levels between > 9.25ng/mL and ≤ 9.25ng/mL had significant difference in HCC histology grade. Multivariate analysis showed that PTX3 level was an independent risk factor related to the overall survival of HCC patients (hazard ratio: 1.058, 95% confidence interval: 1.031– 1.085, P < 0.001).Conclusion: These results support the involvement of PTX3 in the disease progression of HCC and suggest the potential of using serum PTX3 levels as a biomarker for the prognostic prediction of HBV-related HCC patients.Keywords: hepatocellular carcinoma, pentraxin 3, chronic HBV infection, survival, prognosis
format	article
author	Han Q Deng H Fan X Wang X Zhang X Zhang K Li N Lv Y Liu Z
author_facet	Han Q Deng H Fan X Wang X Zhang X Zhang K Li N Lv Y Liu Z
author_sort	Han Q
title	Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma
title_short	Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma
title_full	Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma
title_fullStr	Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma
title_full_unstemmed	Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma
title_sort	increased serum pentraxin 3 levels are associated with poor prognosis of hepatitis b virus-related hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/dcdcb415d6d745c0aff29aa25324c745
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Increased Serum Pentraxin 3 Levels are Associated with Poor Prognosis of Hepatitis B Virus-Related Hepatocellular Carcinoma

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