Vitreous estrogen levels in patients with an idiopathic macular hole

Naoki Inokuchi,1 Tsunehiko Ikeda,2 Kimitoshi Nakamura,3 Seita Morishita,2 Masanori Fukumoto,2 Teruyo Kida,2 Hidehiro Oku2 1Inokuchi Eye Clinic, Suita-City Osaka, Japan; 2Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan; 3Nakamura Eye Clinic, Matsumoto-City, Nagano,...

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Autores principales:	Inokuchi N, Ikeda T, Nakamura K, Morishita S, Fukumoto M, Kida T, Oku H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/dcde28978ddd405ab5818b9df82a0252
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spelling	oai:doaj.org-article:dcde28978ddd405ab5818b9df82a02522021-12-02T04:37:48ZVitreous estrogen levels in patients with an idiopathic macular hole1177-5483https://doaj.org/article/dcde28978ddd405ab5818b9df82a02522015-03-01T00:00:00Zhttp://www.dovepress.com/vitreous-estrogen-levels-in-patients-with-an-idiopathic-macular-hole-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Naoki Inokuchi,1 Tsunehiko Ikeda,2 Kimitoshi Nakamura,3 Seita Morishita,2 Masanori Fukumoto,2 Teruyo Kida,2 Hidehiro Oku2 1Inokuchi Eye Clinic, Suita-City Osaka, Japan; 2Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan; 3Nakamura Eye Clinic, Matsumoto-City, Nagano, Japan Purpose: Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease. The purpose of the present study was to investigate the vitreous levels of estrone (E1) and estradiol (E2) in subjects with an idiopathic macular hole (IMH).Methods: Vitreous samples were obtained from ten female patients with an IMH and from nine female patients with other retinal diseases (six with rhegmatogenous retinal detachment and three with age-related macular degeneration) as a control at the time of vitreous surgery. E1 and E2 levels in the vitreous samples were then determined using the Coat-A-Count® Estradiol Radioimmunoassay (RIA) Kit and the DSL-70 Estrone RIA Kit, respectively.Results: The mean vitreous levels of E1 and E2 in the subjects with IMH were 1.83±2.00 pg/mL and 7.03±2.97 pg/mL, respectively, whereas in the control subjects they were 2.42±1.25 pg/mL and 4.90±2.90 pg/mL, respectively. Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).Conclusion: The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association. Keywords: estradiol, estrone, idiopathic macular hole, vitreous surgery, radioimmunoassayInokuchi NIkeda TNakamura KMorishita SFukumoto MKida TOku HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 549-552 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Inokuchi N Ikeda T Nakamura K Morishita S Fukumoto M Kida T Oku H Vitreous estrogen levels in patients with an idiopathic macular hole
description	Naoki Inokuchi,1 Tsunehiko Ikeda,2 Kimitoshi Nakamura,3 Seita Morishita,2 Masanori Fukumoto,2 Teruyo Kida,2 Hidehiro Oku2 1Inokuchi Eye Clinic, Suita-City Osaka, Japan; 2Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan; 3Nakamura Eye Clinic, Matsumoto-City, Nagano, Japan Purpose: Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease. The purpose of the present study was to investigate the vitreous levels of estrone (E1) and estradiol (E2) in subjects with an idiopathic macular hole (IMH).Methods: Vitreous samples were obtained from ten female patients with an IMH and from nine female patients with other retinal diseases (six with rhegmatogenous retinal detachment and three with age-related macular degeneration) as a control at the time of vitreous surgery. E1 and E2 levels in the vitreous samples were then determined using the Coat-A-Count® Estradiol Radioimmunoassay (RIA) Kit and the DSL-70 Estrone RIA Kit, respectively.Results: The mean vitreous levels of E1 and E2 in the subjects with IMH were 1.83±2.00 pg/mL and 7.03±2.97 pg/mL, respectively, whereas in the control subjects they were 2.42±1.25 pg/mL and 4.90±2.90 pg/mL, respectively. Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).Conclusion: The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association. Keywords: estradiol, estrone, idiopathic macular hole, vitreous surgery, radioimmunoassay
format	article
author	Inokuchi N Ikeda T Nakamura K Morishita S Fukumoto M Kida T Oku H
author_facet	Inokuchi N Ikeda T Nakamura K Morishita S Fukumoto M Kida T Oku H
author_sort	Inokuchi N
title	Vitreous estrogen levels in patients with an idiopathic macular hole
title_short	Vitreous estrogen levels in patients with an idiopathic macular hole
title_full	Vitreous estrogen levels in patients with an idiopathic macular hole
title_fullStr	Vitreous estrogen levels in patients with an idiopathic macular hole
title_full_unstemmed	Vitreous estrogen levels in patients with an idiopathic macular hole
title_sort	vitreous estrogen levels in patients with an idiopathic macular hole
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/dcde28978ddd405ab5818b9df82a0252
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Vitreous estrogen levels in patients with an idiopathic macular hole

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