Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.

<h4>Objective</h4>Diagnostic ratios calculated from urinary steroid hormone metabolites are used as a measure for the relative activity of steroidogenic enzymes or pathways in the clinical investigation of steroid metabolism disorders. However, population-based sex- and age-specific refe...

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Autores principales:	Valentin Rousson, Daniel Ackermann, Belen Ponte, Menno Pruijm, Idris Guessous, Claudia H d'Uscio, Georg Ehret, Geneviève Escher, Antoinette Pechère-Bertschi, Michael Groessl, Pierre-Yves Martin, Michel Burnier, Bernhard Dick, Murielle Bochud, Bruno Vogt, Nasser A Dhayat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcdebe85ad7d48c2b4293cbd39dce1a8
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spelling	oai:doaj.org-article:dcdebe85ad7d48c2b4293cbd39dce1a82021-12-02T20:09:37ZSex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.1932-620310.1371/journal.pone.0253975https://doaj.org/article/dcdebe85ad7d48c2b4293cbd39dce1a82021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253975https://doaj.org/toc/1932-6203<h4>Objective</h4>Diagnostic ratios calculated from urinary steroid hormone metabolites are used as a measure for the relative activity of steroidogenic enzymes or pathways in the clinical investigation of steroid metabolism disorders. However, population-based sex- and age-specific reference intervals and day-night differences in adults are lacking.<h4>Methods</h4>Sixty-five diagnostic ratios were calculated from steroid metabolites measured by GC-MS in day- and night-time and in 24-hour urine from 1128 adults recruited within the Swiss Kidney Project on Genes in Hypertension (SKIPOGH), a population-based, multicenter cohort study. Differences related to sex, age and day- and night-time were evaluated and reference curves in function of age and sex were modelled by multivariable linear mixed regression for diagnostic ratios and were compared to values from the literature.<h4>Results</h4>Most ratios had sex- and age-specific relationships. For each ratio, percentiles were plotted in function of age and sex in order to create reference curves and sex- and age-specific reference intervals derived from 2.5th and 97.5th percentiles were obtained. Most ratios reflected a higher enzyme activity during the day compared to the night.<h4>Conclusions</h4>Sex- and age-specific references for 24 hours, day and night urine steroid metabolite ratios may help distinguishing between health and disease when investigating human disorders affecting steroid synthesis and metabolism. The day-night differences observed for most of the diagnostic ratios suggest a circadian rhythm for enzymes involved in human steroid hormones metabolism.Valentin RoussonDaniel AckermannBelen PonteMenno PruijmIdris GuessousClaudia H d'UscioGeorg EhretGeneviève EscherAntoinette Pechère-BertschiMichael GroesslPierre-Yves MartinMichel BurnierBernhard DickMurielle BochudBruno VogtNasser A DhayatPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253975 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valentin Rousson Daniel Ackermann Belen Ponte Menno Pruijm Idris Guessous Claudia H d'Uscio Georg Ehret Geneviève Escher Antoinette Pechère-Bertschi Michael Groessl Pierre-Yves Martin Michel Burnier Bernhard Dick Murielle Bochud Bruno Vogt Nasser A Dhayat Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.
description	<h4>Objective</h4>Diagnostic ratios calculated from urinary steroid hormone metabolites are used as a measure for the relative activity of steroidogenic enzymes or pathways in the clinical investigation of steroid metabolism disorders. However, population-based sex- and age-specific reference intervals and day-night differences in adults are lacking.<h4>Methods</h4>Sixty-five diagnostic ratios were calculated from steroid metabolites measured by GC-MS in day- and night-time and in 24-hour urine from 1128 adults recruited within the Swiss Kidney Project on Genes in Hypertension (SKIPOGH), a population-based, multicenter cohort study. Differences related to sex, age and day- and night-time were evaluated and reference curves in function of age and sex were modelled by multivariable linear mixed regression for diagnostic ratios and were compared to values from the literature.<h4>Results</h4>Most ratios had sex- and age-specific relationships. For each ratio, percentiles were plotted in function of age and sex in order to create reference curves and sex- and age-specific reference intervals derived from 2.5th and 97.5th percentiles were obtained. Most ratios reflected a higher enzyme activity during the day compared to the night.<h4>Conclusions</h4>Sex- and age-specific references for 24 hours, day and night urine steroid metabolite ratios may help distinguishing between health and disease when investigating human disorders affecting steroid synthesis and metabolism. The day-night differences observed for most of the diagnostic ratios suggest a circadian rhythm for enzymes involved in human steroid hormones metabolism.
format	article
author	Valentin Rousson Daniel Ackermann Belen Ponte Menno Pruijm Idris Guessous Claudia H d'Uscio Georg Ehret Geneviève Escher Antoinette Pechère-Bertschi Michael Groessl Pierre-Yves Martin Michel Burnier Bernhard Dick Murielle Bochud Bruno Vogt Nasser A Dhayat
author_facet	Valentin Rousson Daniel Ackermann Belen Ponte Menno Pruijm Idris Guessous Claudia H d'Uscio Georg Ehret Geneviève Escher Antoinette Pechère-Bertschi Michael Groessl Pierre-Yves Martin Michel Burnier Bernhard Dick Murielle Bochud Bruno Vogt Nasser A Dhayat
author_sort	Valentin Rousson
title	Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.
title_short	Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.
title_full	Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.
title_fullStr	Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.
title_full_unstemmed	Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.
title_sort	sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dcdebe85ad7d48c2b4293cbd39dce1a8
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Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults.

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