Insufficient antibody validation challenges oestrogen receptor beta research

A large body of work into the role of oestrogen receptor b (ERb) in breast cancer is contradictory, hindering future progress. Here the authors conduct extensive validation of anti-ERb antibodies , and show that normal and cancerous breast tissue do not express ERb, consistent with RNA-seq data.

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Autores principales:	Sandra Andersson, Mårten Sundberg, Nusa Pristovsek, Ahmed Ibrahim, Philip Jonsson, Borbala Katona, Carl-Magnus Clausson, Agata Zieba, Margareta Ramström, Ola Söderberg, Cecilia Williams, Anna Asplund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dcdf449150464c8b9fd9103cfd32d3ef
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spelling	oai:doaj.org-article:dcdf449150464c8b9fd9103cfd32d3ef2021-12-02T14:42:40ZInsufficient antibody validation challenges oestrogen receptor beta research10.1038/ncomms158402041-1723https://doaj.org/article/dcdf449150464c8b9fd9103cfd32d3ef2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15840https://doaj.org/toc/2041-1723A large body of work into the role of oestrogen receptor b (ERb) in breast cancer is contradictory, hindering future progress. Here the authors conduct extensive validation of anti-ERb antibodies , and show that normal and cancerous breast tissue do not express ERb, consistent with RNA-seq data.Sandra AnderssonMårten SundbergNusa PristovsekAhmed IbrahimPhilip JonssonBorbala KatonaCarl-Magnus ClaussonAgata ZiebaMargareta RamströmOla SöderbergCecilia WilliamsAnna AsplundNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandra Andersson Mårten Sundberg Nusa Pristovsek Ahmed Ibrahim Philip Jonsson Borbala Katona Carl-Magnus Clausson Agata Zieba Margareta Ramström Ola Söderberg Cecilia Williams Anna Asplund Insufficient antibody validation challenges oestrogen receptor beta research
description	A large body of work into the role of oestrogen receptor b (ERb) in breast cancer is contradictory, hindering future progress. Here the authors conduct extensive validation of anti-ERb antibodies , and show that normal and cancerous breast tissue do not express ERb, consistent with RNA-seq data.
format	article
author	Sandra Andersson Mårten Sundberg Nusa Pristovsek Ahmed Ibrahim Philip Jonsson Borbala Katona Carl-Magnus Clausson Agata Zieba Margareta Ramström Ola Söderberg Cecilia Williams Anna Asplund
author_facet	Sandra Andersson Mårten Sundberg Nusa Pristovsek Ahmed Ibrahim Philip Jonsson Borbala Katona Carl-Magnus Clausson Agata Zieba Margareta Ramström Ola Söderberg Cecilia Williams Anna Asplund
author_sort	Sandra Andersson
title	Insufficient antibody validation challenges oestrogen receptor beta research
title_short	Insufficient antibody validation challenges oestrogen receptor beta research
title_full	Insufficient antibody validation challenges oestrogen receptor beta research
title_fullStr	Insufficient antibody validation challenges oestrogen receptor beta research
title_full_unstemmed	Insufficient antibody validation challenges oestrogen receptor beta research
title_sort	insufficient antibody validation challenges oestrogen receptor beta research
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dcdf449150464c8b9fd9103cfd32d3ef
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Insufficient antibody validation challenges oestrogen receptor beta research

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