Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity

Yuling Liu,1,* Yingqi Xu,2,* Minghui Wu,3 Lijiao Fan,1 Chengwei He,2 Jian-Bo Wan,2 Peng Li,2 Meiwan Chen,2 Hui Li11Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2State Key Laboratory of Quality Research in Chinese Medic...

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Autores principales:	Liu Y, Xu Y, Wu M, Fan L, He C, Wan JB, Li P, Chen M, Li H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Pluronic F68 Vitamin E succinate Mitoxantrone polymer micelles cancer therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dce028bbec3049aa9e78bee6fce01ba7
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spelling	oai:doaj.org-article:dce028bbec3049aa9e78bee6fce01ba72021-12-02T05:14:22ZVitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity1178-2013https://doaj.org/article/dce028bbec3049aa9e78bee6fce01ba72016-07-01T00:00:00Zhttps://www.dovepress.com/vitamin-e-succinate-conjugated-f68-micelles-for-mitoxantrone-delivery--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuling Liu,1,* Yingqi Xu,2,* Minghui Wu,3 Lijiao Fan,1 Chengwei He,2 Jian-Bo Wan,2 Peng Li,2 Meiwan Chen,2 Hui Li11Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China; 3Department of Cell Biology and Anatomy, School of Medicine, University of Florida, Gainesville, FL, USA *These authors contributed equally to this work Abstract: Mitoxantrone (MIT) is a chemotherapeutic agent with promising anticancer efficacy. In this study, Pluronic F68-vitamine E succinate (F68-VES) amphiphilic polymer micelles were developed for delivering MIT and enhancing its anticancer activity. MIT-loaded F68–VES (F68–VES/MIT) micelles were prepared via the solvent evaporation method with self-assembly under aqueous conditions. F68–VES/MIT micelles were found to be of optimal particle size with the narrow size distribution. Transmission electron microscopy images of F68–VES/MIT micelles showed homogeneous spherical shapes and smooth surfaces. F68–VES micelles had a low critical micelle concentration value of 3.311 mg/L, as well as high encapsulation efficiency and drug loading. Moreover, F68–VES/MIT micelles were stable in the presence of fetal bovine serum for 24 hours and maintained sustained drug release in vitro. Remarkably, the half maximal inhibitory concentration (IC50) value of F68–VES/MIT micelles was lower than that of free MIT in both MDA-MB-231 and MCF-7 cells (two human breast cancer cell lines). In addition, compared with free MIT, there was an increased trend of apoptosis and cellular uptake of F68–VES/MIT micelles in MDA-MB-231 cells. Taken together, these results indicated that F68–VES polymer micelles were able to effectively deliver MIT and largely improve its potency in cancer therapy. Keywords: F68, vitamin E succinate, mitoxantrone, polymer micelles, cancer therapyLiu YXu YWu MFan LHe CWan JBLi PChen MLi HDove Medical PressarticlePluronic F68Vitamin E succinateMitoxantronepolymer micellescancer therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3167-3178 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pluronic F68 Vitamin E succinate Mitoxantrone polymer micelles cancer therapy Medicine (General) R5-920
spellingShingle	Pluronic F68 Vitamin E succinate Mitoxantrone polymer micelles cancer therapy Medicine (General) R5-920 Liu Y Xu Y Wu M Fan L He C Wan JB Li P Chen M Li H Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity
description	Yuling Liu,1,* Yingqi Xu,2,* Minghui Wu,3 Lijiao Fan,1 Chengwei He,2 Jian-Bo Wan,2 Peng Li,2 Meiwan Chen,2 Hui Li11Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China; 3Department of Cell Biology and Anatomy, School of Medicine, University of Florida, Gainesville, FL, USA *These authors contributed equally to this work Abstract: Mitoxantrone (MIT) is a chemotherapeutic agent with promising anticancer efficacy. In this study, Pluronic F68-vitamine E succinate (F68-VES) amphiphilic polymer micelles were developed for delivering MIT and enhancing its anticancer activity. MIT-loaded F68–VES (F68–VES/MIT) micelles were prepared via the solvent evaporation method with self-assembly under aqueous conditions. F68–VES/MIT micelles were found to be of optimal particle size with the narrow size distribution. Transmission electron microscopy images of F68–VES/MIT micelles showed homogeneous spherical shapes and smooth surfaces. F68–VES micelles had a low critical micelle concentration value of 3.311 mg/L, as well as high encapsulation efficiency and drug loading. Moreover, F68–VES/MIT micelles were stable in the presence of fetal bovine serum for 24 hours and maintained sustained drug release in vitro. Remarkably, the half maximal inhibitory concentration (IC50) value of F68–VES/MIT micelles was lower than that of free MIT in both MDA-MB-231 and MCF-7 cells (two human breast cancer cell lines). In addition, compared with free MIT, there was an increased trend of apoptosis and cellular uptake of F68–VES/MIT micelles in MDA-MB-231 cells. Taken together, these results indicated that F68–VES polymer micelles were able to effectively deliver MIT and largely improve its potency in cancer therapy. Keywords: F68, vitamin E succinate, mitoxantrone, polymer micelles, cancer therapy
format	article
author	Liu Y Xu Y Wu M Fan L He C Wan JB Li P Chen M Li H
author_facet	Liu Y Xu Y Wu M Fan L He C Wan JB Li P Chen M Li H
author_sort	Liu Y
title	Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity
title_short	Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity
title_full	Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity
title_fullStr	Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity
title_full_unstemmed	Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity
title_sort	vitamin e succinate-conjugated f68 micelles for mitoxantrone delivery in enhancing anticancer activity
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/dce028bbec3049aa9e78bee6fce01ba7
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Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity

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