LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

Mutations in LRRK2 and GBA1, which encodes glucocerebrosidase (GCase), are associated with Parkinson’s disease. Here the authors show that LRRK2 is a negative regulator of lysosomal GCase activity, using dopaminergic neurons derived from iPSCs from PD patients with LRRK2 mutations.

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Autores principales:	Daniel Ysselstein, Maria Nguyen, Tiffany J. Young, Alex Severino, Michael Schwake, Kalpana Merchant, Dimitri Krainc
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dce1b24fa3264d3787c4092c8b341351
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spelling	oai:doaj.org-article:dce1b24fa3264d3787c4092c8b3413512021-12-02T17:32:23ZLRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients10.1038/s41467-019-13413-w2041-1723https://doaj.org/article/dce1b24fa3264d3787c4092c8b3413512019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13413-whttps://doaj.org/toc/2041-1723Mutations in LRRK2 and GBA1, which encodes glucocerebrosidase (GCase), are associated with Parkinson’s disease. Here the authors show that LRRK2 is a negative regulator of lysosomal GCase activity, using dopaminergic neurons derived from iPSCs from PD patients with LRRK2 mutations.Daniel YsselsteinMaria NguyenTiffany J. YoungAlex SeverinoMichael SchwakeKalpana MerchantDimitri KraincNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Ysselstein Maria Nguyen Tiffany J. Young Alex Severino Michael Schwake Kalpana Merchant Dimitri Krainc LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
description	Mutations in LRRK2 and GBA1, which encodes glucocerebrosidase (GCase), are associated with Parkinson’s disease. Here the authors show that LRRK2 is a negative regulator of lysosomal GCase activity, using dopaminergic neurons derived from iPSCs from PD patients with LRRK2 mutations.
format	article
author	Daniel Ysselstein Maria Nguyen Tiffany J. Young Alex Severino Michael Schwake Kalpana Merchant Dimitri Krainc
author_facet	Daniel Ysselstein Maria Nguyen Tiffany J. Young Alex Severino Michael Schwake Kalpana Merchant Dimitri Krainc
author_sort	Daniel Ysselstein
title	LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
title_short	LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
title_full	LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
title_fullStr	LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
title_full_unstemmed	LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
title_sort	lrrk2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from parkinson’s disease patients
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dce1b24fa3264d3787c4092c8b341351
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LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients

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