Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform

Sakthivel Ramasamy,1 Devasier Bennet,1 Sanghyo Kim1,2 1Department of Bionanotechnology, Gachon University, Gyeonggi-Do, Republic of Korea; 2Graduate Gachon Medical Research Institute, Gil Medical Center, Incheon, Republic of Korea Abstract: This review will present a brief discu...

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Autores principales:	Ramasamy S, Bennet D, Kim S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dce652605bfb486783379fd6d1a0ba31
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spelling	oai:doaj.org-article:dce652605bfb486783379fd6d1a0ba312021-12-02T02:16:46ZDrug and bioactive molecule screening based on a bioelectrical impedance cell culture platform1178-2013https://doaj.org/article/dce652605bfb486783379fd6d1a0ba312014-12-01T00:00:00Zhttp://www.dovepress.com/drug-and-bioactive-molecule-screening-based-on-a-bioelectrical-impedan-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Sakthivel Ramasamy,1 Devasier Bennet,1 Sanghyo Kim1,2 1Department of Bionanotechnology, Gachon University, Gyeonggi-Do, Republic of Korea; 2Graduate Gachon Medical Research Institute, Gil Medical Center, Incheon, Republic of Korea Abstract: This review will present a brief discussion on the recent advancements of bioelectrical impedance cell-based biosensors, especially the electric cell-substrate impedance sensing (ECIS) system for screening of various bioactive molecules. The different technical integrations of various chip types, working principles, measurement systems, and applications for drug targeting of molecules in cells are highlighted in this paper. Screening of bioactive molecules based on electric cell-substrate impedance sensing is a trial-and-error process toward the development of therapeutically active agents for drug discovery and therapeutics. In general, bioactive molecule screening can be used to identify active molecular targets for various diseases and toxicity at the cellular level with nanoscale resolution. In the innovation and screening of new drugs or bioactive molecules, the activeness, the efficacy of the compound, and safety in biological systems are the main concerns on which determination of drug candidates is based. Further, drug discovery and screening of compounds are often performed in cell-based test systems in order to reduce costs and save time. Moreover, this system can provide more relevant results in in vivo studies, as well as high-throughput drug screening for various diseases during the early stages of drug discovery. Recently, MEMS technologies and integration with image detection techniques have been employed successfully. These new technologies and their possible ongoing transformations are addressed. Select reports are outlined, and not all the work that has been performed in the field of drug screening and development is covered. Keywords: screening of bioactive agents, impedance-based cell study, electric cell-substrate impedance sensing (ECIS), high-throughput screening, real-time drug evaluationRamasamy SBennet DKim SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 5789-5809 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ramasamy S Bennet D Kim S Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform
description	Sakthivel Ramasamy,1 Devasier Bennet,1 Sanghyo Kim1,2 1Department of Bionanotechnology, Gachon University, Gyeonggi-Do, Republic of Korea; 2Graduate Gachon Medical Research Institute, Gil Medical Center, Incheon, Republic of Korea Abstract: This review will present a brief discussion on the recent advancements of bioelectrical impedance cell-based biosensors, especially the electric cell-substrate impedance sensing (ECIS) system for screening of various bioactive molecules. The different technical integrations of various chip types, working principles, measurement systems, and applications for drug targeting of molecules in cells are highlighted in this paper. Screening of bioactive molecules based on electric cell-substrate impedance sensing is a trial-and-error process toward the development of therapeutically active agents for drug discovery and therapeutics. In general, bioactive molecule screening can be used to identify active molecular targets for various diseases and toxicity at the cellular level with nanoscale resolution. In the innovation and screening of new drugs or bioactive molecules, the activeness, the efficacy of the compound, and safety in biological systems are the main concerns on which determination of drug candidates is based. Further, drug discovery and screening of compounds are often performed in cell-based test systems in order to reduce costs and save time. Moreover, this system can provide more relevant results in in vivo studies, as well as high-throughput drug screening for various diseases during the early stages of drug discovery. Recently, MEMS technologies and integration with image detection techniques have been employed successfully. These new technologies and their possible ongoing transformations are addressed. Select reports are outlined, and not all the work that has been performed in the field of drug screening and development is covered. Keywords: screening of bioactive agents, impedance-based cell study, electric cell-substrate impedance sensing (ECIS), high-throughput screening, real-time drug evaluation
format	article
author	Ramasamy S Bennet D Kim S
author_facet	Ramasamy S Bennet D Kim S
author_sort	Ramasamy S
title	Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform
title_short	Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform
title_full	Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform
title_fullStr	Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform
title_full_unstemmed	Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform
title_sort	drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/dce652605bfb486783379fd6d1a0ba31
work_keys_str_mv	AT ramasamys drugandbioactivemoleculescreeningbasedonabioelectricalimpedancecellcultureplatform AT bennetd drugandbioactivemoleculescreeningbasedonabioelectricalimpedancecellcultureplatform AT kims drugandbioactivemoleculescreeningbasedonabioelectricalimpedancecellcultureplatform
_version_	1718402623894192128

Drug and bioactive molecule screening based on a bioelectrical impedance cell culture platform

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