Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro

The authors form pre-epicardial cells (PECs) from hiPSC-derived lateral plate mesoderm on treating with BMP4, RA and VEGF, and co-culture these PECs with cardiomyocytes, inducing cardiomyocyte aggregation, proliferation and network formation with more mature structures and improved beating/contracti...

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Autores principales:	Jun Jie Tan, Jacques P. Guyette, Kenji Miki, Ling Xiao, Gurbani Kaur, Tong Wu, Liye Zhu, Katrina J. Hansen, King-Hwa Ling, David J. Milan, Harald C. Ott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dce68985cbe8407fb378c24f42d8af61
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spelling	oai:doaj.org-article:dce68985cbe8407fb378c24f42d8af612021-12-02T17:08:38ZHuman iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro10.1038/s41467-021-24921-z2041-1723https://doaj.org/article/dce68985cbe8407fb378c24f42d8af612021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24921-zhttps://doaj.org/toc/2041-1723The authors form pre-epicardial cells (PECs) from hiPSC-derived lateral plate mesoderm on treating with BMP4, RA and VEGF, and co-culture these PECs with cardiomyocytes, inducing cardiomyocyte aggregation, proliferation and network formation with more mature structures and improved beating/contractility.Jun Jie TanJacques P. GuyetteKenji MikiLing XiaoGurbani KaurTong WuLiye ZhuKatrina J. HansenKing-Hwa LingDavid J. MilanHarald C. OttNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Jie Tan Jacques P. Guyette Kenji Miki Ling Xiao Gurbani Kaur Tong Wu Liye Zhu Katrina J. Hansen King-Hwa Ling David J. Milan Harald C. Ott Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
description	The authors form pre-epicardial cells (PECs) from hiPSC-derived lateral plate mesoderm on treating with BMP4, RA and VEGF, and co-culture these PECs with cardiomyocytes, inducing cardiomyocyte aggregation, proliferation and network formation with more mature structures and improved beating/contractility.
format	article
author	Jun Jie Tan Jacques P. Guyette Kenji Miki Ling Xiao Gurbani Kaur Tong Wu Liye Zhu Katrina J. Hansen King-Hwa Ling David J. Milan Harald C. Ott
author_facet	Jun Jie Tan Jacques P. Guyette Kenji Miki Ling Xiao Gurbani Kaur Tong Wu Liye Zhu Katrina J. Hansen King-Hwa Ling David J. Milan Harald C. Ott
author_sort	Jun Jie Tan
title	Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
title_short	Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
title_full	Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
title_fullStr	Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
title_full_unstemmed	Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
title_sort	human ips-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dce68985cbe8407fb378c24f42d8af61
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Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro

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