Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro

Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro

The authors form pre-epicardial cells (PECs) from hiPSC-derived lateral plate mesoderm on treating with BMP4, RA and VEGF, and co-culture these PECs with cardiomyocytes, inducing cardiomyocyte aggregation, proliferation and network formation with more mature structures and improved beating/contracti...

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Autores principales: Jun Jie Tan, Jacques P. Guyette, Kenji Miki, Ling Xiao, Gurbani Kaur, Tong Wu, Liye Zhu, Katrina J. Hansen, King-Hwa Ling, David J. Milan, Harald C. Ott
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/dce68985cbe8407fb378c24f42d8af61
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