Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel

The aim of this study was to re-evaluate archived samples of canine soft tissue sarcomas (STSs) morphologically consistent with peripheral nerve sheath tumors (PNSTs). In each case, an immunohistochemical panel was applied, including α-SMA, calponin, desmin, S-100, GFAP, NSE and Olig2, in order to a...

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Autores principales:	Sirri Rubina, Sabattini Silvia, Bettini Giuliano, Mandrioli Luciana
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	canine egfr immunohistochemistry pnst soft tissue sarcomas Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/dce75eb5b4d641f0a8a307a0cab9aba7
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spelling	oai:doaj.org-article:dce75eb5b4d641f0a8a307a0cab9aba72021-11-17T21:27:51ZReclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel1820-744810.1515/acve-2016-0039https://doaj.org/article/dce75eb5b4d641f0a8a307a0cab9aba72016-12-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0039https://doaj.org/toc/1820-7448The aim of this study was to re-evaluate archived samples of canine soft tissue sarcomas (STSs) morphologically consistent with peripheral nerve sheath tumors (PNSTs). In each case, an immunohistochemical panel was applied, including α-SMA, calponin, desmin, S-100, GFAP, NSE and Olig2, in order to assess whether the phenotype was consistent with the tumor histological appearance. Additionally, the expression of EGFR, a marker with potential therapeutic implications in malignant PNSTs, was evaluated. Twenty-one tumors were included. Fourteen cases (66.7%) were positive for one or more muscular markers and were reclassified as perivascular tumors (PWTs). A positive labeling for S-100 was observed in one tumor (4.8%), thus classifi ed as PNST. The other 6 tumors were generically classified as poorly differentiated STSs. No unique histopathological feature was observed within the three groups. NSE and Olig2 labeling was aspecific and not useful for diagnostic purposes. GFAP was negative in all cases. Six cases (28.6%) were positive for EGFR, including the PNST. Even after the application of a wide immunohistochemical panel, distinguishing between PNSTs and PWTs remains a challenge. Finally, a subgroup of cases cannot be classified based on light microscopy alone.Sirri RubinaSabattini SilviaBettini GiulianoMandrioli LucianaSciendoarticlecanineegfrimmunohistochemistrypnstsoft tissue sarcomasVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 4, Pp 455-465 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	canine egfr immunohistochemistry pnst soft tissue sarcomas Veterinary medicine SF600-1100
spellingShingle	canine egfr immunohistochemistry pnst soft tissue sarcomas Veterinary medicine SF600-1100 Sirri Rubina Sabattini Silvia Bettini Giuliano Mandrioli Luciana Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel
description	The aim of this study was to re-evaluate archived samples of canine soft tissue sarcomas (STSs) morphologically consistent with peripheral nerve sheath tumors (PNSTs). In each case, an immunohistochemical panel was applied, including α-SMA, calponin, desmin, S-100, GFAP, NSE and Olig2, in order to assess whether the phenotype was consistent with the tumor histological appearance. Additionally, the expression of EGFR, a marker with potential therapeutic implications in malignant PNSTs, was evaluated. Twenty-one tumors were included. Fourteen cases (66.7%) were positive for one or more muscular markers and were reclassified as perivascular tumors (PWTs). A positive labeling for S-100 was observed in one tumor (4.8%), thus classifi ed as PNST. The other 6 tumors were generically classified as poorly differentiated STSs. No unique histopathological feature was observed within the three groups. NSE and Olig2 labeling was aspecific and not useful for diagnostic purposes. GFAP was negative in all cases. Six cases (28.6%) were positive for EGFR, including the PNST. Even after the application of a wide immunohistochemical panel, distinguishing between PNSTs and PWTs remains a challenge. Finally, a subgroup of cases cannot be classified based on light microscopy alone.
format	article
author	Sirri Rubina Sabattini Silvia Bettini Giuliano Mandrioli Luciana
author_facet	Sirri Rubina Sabattini Silvia Bettini Giuliano Mandrioli Luciana
author_sort	Sirri Rubina
title	Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel
title_short	Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel
title_full	Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel
title_fullStr	Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel
title_full_unstemmed	Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel
title_sort	reclassification of 21 presumptive canine peripheral nerve sheath tumors (pnst) using a literature-based immunohistochemical panel
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/dce75eb5b4d641f0a8a307a0cab9aba7
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Reclassification of 21 Presumptive Canine Peripheral Nerve Sheath Tumors (PNST) Using a Literature-Based Immunohistochemical Panel

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