Complexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons

System identification techniques—projection pursuit regression models (PPRs) and convolutional neural networks (CNNs)—provide state-of-the-art performance in predicting visual cortical neurons’ responses to arbitrary input stimuli. However, the constituent kernels recovered by these methods are ofte...

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Autores principales:	Ziniu Wu, Harold Rockwell, Yimeng Zhang, Shiming Tang, Tai Sing Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dce80bd5117545c39b83f2276e7d9353
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spelling	oai:doaj.org-article:dce80bd5117545c39b83f2276e7d93532021-11-18T05:52:51ZComplexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons1553-734X1553-7358https://doaj.org/article/dce80bd5117545c39b83f2276e7d93532021-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589190/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358System identification techniques—projection pursuit regression models (PPRs) and convolutional neural networks (CNNs)—provide state-of-the-art performance in predicting visual cortical neurons’ responses to arbitrary input stimuli. However, the constituent kernels recovered by these methods are often noisy and lack coherent structure, making it difficult to understand the underlying component features of a neuron’s receptive field. In this paper, we show that using a dictionary of diverse kernels with complex shapes learned from natural scenes based on efficient coding theory, as the front-end for PPRs and CNNs can improve their performance in neuronal response prediction as well as algorithmic data efficiency and convergence speed. Extensive experimental results also indicate that these sparse-code kernels provide important information on the component features of a neuron’s receptive field. In addition, we find that models with the complex-shaped sparse code front-end are significantly better than models with a standard orientation-selective Gabor filter front-end for modeling V1 neurons that have been found to exhibit complex pattern selectivity. We show that the relative performance difference due to these two front-ends can be used to produce a sensitive metric for detecting complex selectivity in V1 neurons. Author summary Convolution neural networks and projection pursuit regression models are two state-of-the-art approaches to characterizing the neural codes or the receptive fields of neurons in the visual system. However, the constituent kernels recovered by these methods are often noisy and difficult to interpret. Here, we propose an improvement of these standard methods by using a set of neural codes learned from natural scene images based on the convolutional sparse coding theory as priors or the front-end for these methods. We found that this approach improves the model performance in predicting neural responses with less data and with faster convergence for fitting, and allows a possible interpretation of the constituents of the receptive fields in terms of the dictionary learned from natural scenes. The relative performance difference due to these two front-ends has been shown to produce an effective metric for detecting complex selectivity in V1 neurons.Ziniu WuHarold RockwellYimeng ZhangShiming TangTai Sing LeePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ziniu Wu Harold Rockwell Yimeng Zhang Shiming Tang Tai Sing Lee Complexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons
description	System identification techniques—projection pursuit regression models (PPRs) and convolutional neural networks (CNNs)—provide state-of-the-art performance in predicting visual cortical neurons’ responses to arbitrary input stimuli. However, the constituent kernels recovered by these methods are often noisy and lack coherent structure, making it difficult to understand the underlying component features of a neuron’s receptive field. In this paper, we show that using a dictionary of diverse kernels with complex shapes learned from natural scenes based on efficient coding theory, as the front-end for PPRs and CNNs can improve their performance in neuronal response prediction as well as algorithmic data efficiency and convergence speed. Extensive experimental results also indicate that these sparse-code kernels provide important information on the component features of a neuron’s receptive field. In addition, we find that models with the complex-shaped sparse code front-end are significantly better than models with a standard orientation-selective Gabor filter front-end for modeling V1 neurons that have been found to exhibit complex pattern selectivity. We show that the relative performance difference due to these two front-ends can be used to produce a sensitive metric for detecting complex selectivity in V1 neurons. Author summary Convolution neural networks and projection pursuit regression models are two state-of-the-art approaches to characterizing the neural codes or the receptive fields of neurons in the visual system. However, the constituent kernels recovered by these methods are often noisy and difficult to interpret. Here, we propose an improvement of these standard methods by using a set of neural codes learned from natural scene images based on the convolutional sparse coding theory as priors or the front-end for these methods. We found that this approach improves the model performance in predicting neural responses with less data and with faster convergence for fitting, and allows a possible interpretation of the constituents of the receptive fields in terms of the dictionary learned from natural scenes. The relative performance difference due to these two front-ends has been shown to produce an effective metric for detecting complex selectivity in V1 neurons.
format	article
author	Ziniu Wu Harold Rockwell Yimeng Zhang Shiming Tang Tai Sing Lee
author_facet	Ziniu Wu Harold Rockwell Yimeng Zhang Shiming Tang Tai Sing Lee
author_sort	Ziniu Wu
title	Complexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons
title_short	Complexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons
title_full	Complexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons
title_fullStr	Complexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons
title_full_unstemmed	Complexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons
title_sort	complexity and diversity in sparse code priors improve receptive field characterization of macaque v1 neurons
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dce80bd5117545c39b83f2276e7d9353
work_keys_str_mv	AT ziniuwu complexityanddiversityinsparsecodepriorsimprovereceptivefieldcharacterizationofmacaquev1neurons AT haroldrockwell complexityanddiversityinsparsecodepriorsimprovereceptivefieldcharacterizationofmacaquev1neurons AT yimengzhang complexityanddiversityinsparsecodepriorsimprovereceptivefieldcharacterizationofmacaquev1neurons AT shimingtang complexityanddiversityinsparsecodepriorsimprovereceptivefieldcharacterizationofmacaquev1neurons AT taisinglee complexityanddiversityinsparsecodepriorsimprovereceptivefieldcharacterizationofmacaquev1neurons
_version_	1718424759566336000

Complexity and diversity in sparse code priors improve receptive field characterization of Macaque V1 neurons

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