A molecular quantitative trait locus map for osteoarthritis

A molecular quantitative trait locus map for osteoarthritis

Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potenti...

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Autores principales: Julia Steinberg, Lorraine Southam, Theodoros I. Roumeliotis, Matthew J. Clark, Raveen L. Jayasuriya, Diane Swift, Karan M. Shah, Natalie C. Butterfield, Roger A. Brooks, Andrew W. McCaskie, J. H. Duncan Bassett, Graham R. Williams, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/dcec7e1450ec48c58e6b36aa6fd093ff
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spelling oai:doaj.org-article:dcec7e1450ec48c58e6b36aa6fd093ff2021-12-02T13:15:06ZA molecular quantitative trait locus map for osteoarthritis10.1038/s41467-021-21593-72041-1723https://doaj.org/article/dcec7e1450ec48c58e6b36aa6fd093ff2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21593-7https://doaj.org/toc/2041-1723Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potential drug treatments.Julia SteinbergLorraine SouthamTheodoros I. RoumeliotisMatthew J. ClarkRaveen L. JayasuriyaDiane SwiftKaran M. ShahNatalie C. ButterfieldRoger A. BrooksAndrew W. McCaskieJ. H. Duncan BassettGraham R. WilliamsJyoti S. ChoudharyJ. Mark WilkinsonEleftheria ZegginiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julia Steinberg
Lorraine Southam
Theodoros I. Roumeliotis
Matthew J. Clark
Raveen L. Jayasuriya
Diane Swift
Karan M. Shah
Natalie C. Butterfield
Roger A. Brooks
Andrew W. McCaskie
J. H. Duncan Bassett
Graham R. Williams
Jyoti S. Choudhary
J. Mark Wilkinson
Eleftheria Zeggini
A molecular quantitative trait locus map for osteoarthritis
description Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potential drug treatments.
format article
author Julia Steinberg
Lorraine Southam
Theodoros I. Roumeliotis
Matthew J. Clark
Raveen L. Jayasuriya
Diane Swift
Karan M. Shah
Natalie C. Butterfield
Roger A. Brooks
Andrew W. McCaskie
J. H. Duncan Bassett
Graham R. Williams
Jyoti S. Choudhary
J. Mark Wilkinson
Eleftheria Zeggini
author_facet Julia Steinberg
Lorraine Southam
Theodoros I. Roumeliotis
Matthew J. Clark
Raveen L. Jayasuriya
Diane Swift
Karan M. Shah
Natalie C. Butterfield
Roger A. Brooks
Andrew W. McCaskie
J. H. Duncan Bassett
Graham R. Williams
Jyoti S. Choudhary
J. Mark Wilkinson
Eleftheria Zeggini
author_sort Julia Steinberg
title A molecular quantitative trait locus map for osteoarthritis
title_short A molecular quantitative trait locus map for osteoarthritis
title_full A molecular quantitative trait locus map for osteoarthritis
title_fullStr A molecular quantitative trait locus map for osteoarthritis
title_full_unstemmed A molecular quantitative trait locus map for osteoarthritis
title_sort molecular quantitative trait locus map for osteoarthritis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/dcec7e1450ec48c58e6b36aa6fd093ff
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