The <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements

Among clinically relevant lineages of <i>Staphylococcus aureus</i>, the lineage or clonal complex 398 (CC398) is of particular interest. Strains from this lineage were only described as livestock colonizers until 2007. Progressively, cases of infection were reported in humans in contact...

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Autores principales:	Floriane Laumay, Hugo Benchetrit, Anna-Rita Corvaglia, Nathalie van der Mee-Marquet, Patrice François
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Staphylococcus aureus</i> CC398 evolution prophages mobile genetic elements Genetics QH426-470
Acceso en línea:	https://doaj.org/article/dcecb9236ecc4702981386e9f8d95a14
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spelling	oai:doaj.org-article:dcecb9236ecc4702981386e9f8d95a142021-11-25T17:41:31ZThe <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements10.3390/genes121117522073-4425https://doaj.org/article/dcecb9236ecc4702981386e9f8d95a142021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1752https://doaj.org/toc/2073-4425Among clinically relevant lineages of <i>Staphylococcus aureus</i>, the lineage or clonal complex 398 (CC398) is of particular interest. Strains from this lineage were only described as livestock colonizers until 2007. Progressively, cases of infection were reported in humans in contact with farm animals, and now, CC398 isolates are increasingly identified as the cause of severe infections even in patients without any contact with animals. These observations suggest that CC398 isolates have spread not only in the community but also in the hospital setting. In addition, several recent studies have reported that CC398 strains are evolving towards increased virulence and antibiotic resistance. Identification of the origin and emergence of this clonal complex could probably benefit future large-scale studies that aim to detect sources of contamination and infection. Current evidence indicates that the evolution of CC398 strains towards these phenotypes has been driven by the acquisition of prophages and other mobile genetic elements. In this short review, we summarize the main knowledge of this major lineage of <i>S. aureus</i> that has become predominant in the human clinic worldwide within a single decade.Floriane LaumayHugo BenchetritAnna-Rita CorvagliaNathalie van der Mee-MarquetPatrice FrançoisMDPI AGarticle<i>Staphylococcus aureus</i>CC398evolutionprophagesmobile genetic elementsGeneticsQH426-470ENGenes, Vol 12, Iss 1752, p 1752 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Staphylococcus aureus</i> CC398 evolution prophages mobile genetic elements Genetics QH426-470
spellingShingle	<i>Staphylococcus aureus</i> CC398 evolution prophages mobile genetic elements Genetics QH426-470 Floriane Laumay Hugo Benchetrit Anna-Rita Corvaglia Nathalie van der Mee-Marquet Patrice François The <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements
description	Among clinically relevant lineages of <i>Staphylococcus aureus</i>, the lineage or clonal complex 398 (CC398) is of particular interest. Strains from this lineage were only described as livestock colonizers until 2007. Progressively, cases of infection were reported in humans in contact with farm animals, and now, CC398 isolates are increasingly identified as the cause of severe infections even in patients without any contact with animals. These observations suggest that CC398 isolates have spread not only in the community but also in the hospital setting. In addition, several recent studies have reported that CC398 strains are evolving towards increased virulence and antibiotic resistance. Identification of the origin and emergence of this clonal complex could probably benefit future large-scale studies that aim to detect sources of contamination and infection. Current evidence indicates that the evolution of CC398 strains towards these phenotypes has been driven by the acquisition of prophages and other mobile genetic elements. In this short review, we summarize the main knowledge of this major lineage of <i>S. aureus</i> that has become predominant in the human clinic worldwide within a single decade.
format	article
author	Floriane Laumay Hugo Benchetrit Anna-Rita Corvaglia Nathalie van der Mee-Marquet Patrice François
author_facet	Floriane Laumay Hugo Benchetrit Anna-Rita Corvaglia Nathalie van der Mee-Marquet Patrice François
author_sort	Floriane Laumay
title	The <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements
title_short	The <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements
title_full	The <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements
title_fullStr	The <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements
title_full_unstemmed	The <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements
title_sort	<i>staphylococcus aureus</i> cc398 lineage: an evolution driven by the acquisition of prophages and other mobile genetic elements
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dcecb9236ecc4702981386e9f8d95a14
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The <i>Staphylococcus aureus</i> CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements

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