Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans

Gene therapy (GT) using haematopoietic stem cells (HSCs) provides an opportunity to trace cell fates in humans, in vivo. Here the authors present evidence in GT patients for a long term lymphoid progenitor population, surviving and maintaining de novo T and NK cell production for years, independentl...

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Autores principales:	Natalia Izotova, Christine Rivat, Cristina Baricordi, Elena Blanco, Danilo Pellin, Eleanor Watt, Athina S. Gkazi, Stuart Adams, Kimberly Gilmour, Jinhua Bayford, Claire Booth, H. Bobby Gaspar, Adrian J. Thrasher, Luca Biasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dced9d3e9d5c441eaba1bc9789351905
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spelling	oai:doaj.org-article:dced9d3e9d5c441eaba1bc97893519052021-12-02T13:30:36ZLong-term lymphoid progenitors independently sustain naïve T and NK cell production in humans10.1038/s41467-021-21834-92041-1723https://doaj.org/article/dced9d3e9d5c441eaba1bc97893519052021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21834-9https://doaj.org/toc/2041-1723Gene therapy (GT) using haematopoietic stem cells (HSCs) provides an opportunity to trace cell fates in humans, in vivo. Here the authors present evidence in GT patients for a long term lymphoid progenitor population, surviving and maintaining de novo T and NK cell production for years, independently from HSCs.Natalia IzotovaChristine RivatCristina BaricordiElena BlancoDanilo PellinEleanor WattAthina S. GkaziStuart AdamsKimberly GilmourJinhua BayfordClaire BoothH. Bobby GasparAdrian J. ThrasherLuca BiascoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natalia Izotova Christine Rivat Cristina Baricordi Elena Blanco Danilo Pellin Eleanor Watt Athina S. Gkazi Stuart Adams Kimberly Gilmour Jinhua Bayford Claire Booth H. Bobby Gaspar Adrian J. Thrasher Luca Biasco Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans
description	Gene therapy (GT) using haematopoietic stem cells (HSCs) provides an opportunity to trace cell fates in humans, in vivo. Here the authors present evidence in GT patients for a long term lymphoid progenitor population, surviving and maintaining de novo T and NK cell production for years, independently from HSCs.
format	article
author	Natalia Izotova Christine Rivat Cristina Baricordi Elena Blanco Danilo Pellin Eleanor Watt Athina S. Gkazi Stuart Adams Kimberly Gilmour Jinhua Bayford Claire Booth H. Bobby Gaspar Adrian J. Thrasher Luca Biasco
author_facet	Natalia Izotova Christine Rivat Cristina Baricordi Elena Blanco Danilo Pellin Eleanor Watt Athina S. Gkazi Stuart Adams Kimberly Gilmour Jinhua Bayford Claire Booth H. Bobby Gaspar Adrian J. Thrasher Luca Biasco
author_sort	Natalia Izotova
title	Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans
title_short	Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans
title_full	Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans
title_fullStr	Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans
title_full_unstemmed	Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans
title_sort	long-term lymphoid progenitors independently sustain naïve t and nk cell production in humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dced9d3e9d5c441eaba1bc9789351905
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Long-term lymphoid progenitors independently sustain naïve T and NK cell production in humans

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