Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Hailun Huang, Shan Wu Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, People’s Republic of ChinaCorrespondence: Shan WuDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guizhou 550001, People’s Republi...

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Autores principales:	Huang H, Wu S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetes diabetic peripheral neuropathy high-resolution ultrasound diagnosis muscle ultrasound Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/dceee40dbc5345e18add984c789ee803
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spelling	oai:doaj.org-article:dceee40dbc5345e18add984c789ee8032021-12-02T13:50:30ZApplication of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy1178-7007https://doaj.org/article/dceee40dbc5345e18add984c789ee8032021-01-01T00:00:00Zhttps://www.dovepress.com/application-of-high-resolution-ultrasound-on-diagnosing-diabetic-perip-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Hailun Huang, Shan Wu Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, People’s Republic of ChinaCorrespondence: Shan WuDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guizhou 550001, People’s Republic of ChinaTel +86 13312231575Email wuwushan@163.comAbstract: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). The typical manifestation is a length-dependent “glove and sock” sensation. At present, diagnosis is mainly dependent on clinical manifestations. Since the pathogenesis is not clear, there are no effective treatment measures. Management consists mainly of glucose control, peripheral nerve nutrition, and other measures to delay the progress of the disease; early diagnosis is therefore crucial to improving prognosis and quality of life for patients with DPN. Due to the lack of obvious symptoms in 50% of patients and the low sensitivity of neuro-electrophysiology to small fibers, the missed diagnosis rate is high. High-resolution ultrasound (HRU), as a convenient noninvasive tool, has been proven by many studies to have excellent clinical value in diagnosing DPN. With the development of related new technology, HRU shows promise for the screening, diagnosing, and follow-up of DPN, which could serve as a biomarker and provide new diagnostic insights. In this paper, we review the ability of HRU to detect nerve cross-sectional area and blood flow, and echo and other image changes, and in showing the characteristics of peripheral nerve morphological changes in patients with DPN. We also explore the application of two other recent technological developments—shear wave elastography (SWE) and ultrasound scoring systems—in improving the diagnostic efficiency of HRU in peripheral neuropathy.Keywords: diabetes, diabetic peripheral neuropathy, high-resolution ultrasound diagnosis, muscle ultrasoundHuang HWu SDove Medical Pressarticlediabetesdiabetic peripheral neuropathyhigh-resolution ultrasound diagnosismuscle ultrasoundSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 139-152 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes diabetic peripheral neuropathy high-resolution ultrasound diagnosis muscle ultrasound Specialties of internal medicine RC581-951
spellingShingle	diabetes diabetic peripheral neuropathy high-resolution ultrasound diagnosis muscle ultrasound Specialties of internal medicine RC581-951 Huang H Wu S Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy
description	Hailun Huang, Shan Wu Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, People’s Republic of ChinaCorrespondence: Shan WuDepartment of Neurology, Affiliated Hospital of Guizhou Medical University, Guizhou 550001, People’s Republic of ChinaTel +86 13312231575Email wuwushan@163.comAbstract: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). The typical manifestation is a length-dependent “glove and sock” sensation. At present, diagnosis is mainly dependent on clinical manifestations. Since the pathogenesis is not clear, there are no effective treatment measures. Management consists mainly of glucose control, peripheral nerve nutrition, and other measures to delay the progress of the disease; early diagnosis is therefore crucial to improving prognosis and quality of life for patients with DPN. Due to the lack of obvious symptoms in 50% of patients and the low sensitivity of neuro-electrophysiology to small fibers, the missed diagnosis rate is high. High-resolution ultrasound (HRU), as a convenient noninvasive tool, has been proven by many studies to have excellent clinical value in diagnosing DPN. With the development of related new technology, HRU shows promise for the screening, diagnosing, and follow-up of DPN, which could serve as a biomarker and provide new diagnostic insights. In this paper, we review the ability of HRU to detect nerve cross-sectional area and blood flow, and echo and other image changes, and in showing the characteristics of peripheral nerve morphological changes in patients with DPN. We also explore the application of two other recent technological developments—shear wave elastography (SWE) and ultrasound scoring systems—in improving the diagnostic efficiency of HRU in peripheral neuropathy.Keywords: diabetes, diabetic peripheral neuropathy, high-resolution ultrasound diagnosis, muscle ultrasound
format	article
author	Huang H Wu S
author_facet	Huang H Wu S
author_sort	Huang H
title	Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy
title_short	Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy
title_full	Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy
title_fullStr	Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy
title_full_unstemmed	Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy
title_sort	application of high-resolution ultrasound on diagnosing diabetic peripheral neuropathy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/dceee40dbc5345e18add984c789ee803
work_keys_str_mv	AT huangh applicationofhighresolutionultrasoundondiagnosingdiabeticperipheralneuropathy AT wus applicationofhighresolutionultrasoundondiagnosingdiabeticperipheralneuropathy
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Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

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