Co-carcinogenic effects of vitamin E in prostate

Abstract A large number of basic researches and observational studies suggested the cancer preventive activity of vitamin E, but large-scale human intervention trials have yielded disappointing results and actually showed a higher incidence of prostate cancer although the mechanisms underlying the i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Fabio Vivarelli, Donatella Canistro, Silvia Cirillo, Alessio Papi, Enzo Spisni, Andrea Vornoli, Clara M. Della Croce, Vincenzo Longo, Paola Franchi, Sandra Filippi, Marco Lucarini, Cristina Zanzi, Francesca Rotondo, Antonello Lorenzini, Silvia Marchionni, Moreno Paolini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
R
Q
Acceso en línea:https://doaj.org/article/dcf912f3c91945589c0624bd7d1c36b9
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:dcf912f3c91945589c0624bd7d1c36b9
record_format dspace
spelling oai:doaj.org-article:dcf912f3c91945589c0624bd7d1c36b92021-12-02T15:09:16ZCo-carcinogenic effects of vitamin E in prostate10.1038/s41598-019-48213-12045-2322https://doaj.org/article/dcf912f3c91945589c0624bd7d1c36b92019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48213-1https://doaj.org/toc/2045-2322Abstract A large number of basic researches and observational studies suggested the cancer preventive activity of vitamin E, but large-scale human intervention trials have yielded disappointing results and actually showed a higher incidence of prostate cancer although the mechanisms underlying the increased risk remain largely unknown. Here we show through in vitro and in vivo studies that vitamin E produces a marked inductive effect on carcinogen-bioactivating enzymes and a pro-oxidant status promoting both DNA damage and cell transformation frequency. First, we found that vitamin E in the human prostate epithelial RWPE-1 cell line has the remarkable ability to upregulate the expression of various phase-I activating cytochrome P450 (CYP) enzymes, including activators of polycyclic aromatic hydrocarbons (PAHs), giving rise to supraphysiological levels of reactive oxygen species. Furthermore, our rat model confirmed that vitamin E in the prostate has a powerful booster effect on CYP enzymes associated with the generation of oxidative stress, thereby favoring lipid-derived electrophile spread that covalently modifies proteins. We show that vitamin E not only causes DNA damage but also promotes cell transformation frequency induced by the PAH-prototype benzo[a]pyrene. Our findings might explain why dietary supplementation with vitamin E increases the prostate cancer risk among healthy men.Fabio VivarelliDonatella CanistroSilvia CirilloAlessio PapiEnzo SpisniAndrea VornoliClara M. Della CroceVincenzo LongoPaola FranchiSandra FilippiMarco LucariniCristina ZanziFrancesca RotondoAntonello LorenziniSilvia MarchionniMoreno PaoliniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Fabio Vivarelli
Donatella Canistro
Silvia Cirillo
Alessio Papi
Enzo Spisni
Andrea Vornoli
Clara M. Della Croce
Vincenzo Longo
Paola Franchi
Sandra Filippi
Marco Lucarini
Cristina Zanzi
Francesca Rotondo
Antonello Lorenzini
Silvia Marchionni
Moreno Paolini
Co-carcinogenic effects of vitamin E in prostate
description Abstract A large number of basic researches and observational studies suggested the cancer preventive activity of vitamin E, but large-scale human intervention trials have yielded disappointing results and actually showed a higher incidence of prostate cancer although the mechanisms underlying the increased risk remain largely unknown. Here we show through in vitro and in vivo studies that vitamin E produces a marked inductive effect on carcinogen-bioactivating enzymes and a pro-oxidant status promoting both DNA damage and cell transformation frequency. First, we found that vitamin E in the human prostate epithelial RWPE-1 cell line has the remarkable ability to upregulate the expression of various phase-I activating cytochrome P450 (CYP) enzymes, including activators of polycyclic aromatic hydrocarbons (PAHs), giving rise to supraphysiological levels of reactive oxygen species. Furthermore, our rat model confirmed that vitamin E in the prostate has a powerful booster effect on CYP enzymes associated with the generation of oxidative stress, thereby favoring lipid-derived electrophile spread that covalently modifies proteins. We show that vitamin E not only causes DNA damage but also promotes cell transformation frequency induced by the PAH-prototype benzo[a]pyrene. Our findings might explain why dietary supplementation with vitamin E increases the prostate cancer risk among healthy men.
format article
author Fabio Vivarelli
Donatella Canistro
Silvia Cirillo
Alessio Papi
Enzo Spisni
Andrea Vornoli
Clara M. Della Croce
Vincenzo Longo
Paola Franchi
Sandra Filippi
Marco Lucarini
Cristina Zanzi
Francesca Rotondo
Antonello Lorenzini
Silvia Marchionni
Moreno Paolini
author_facet Fabio Vivarelli
Donatella Canistro
Silvia Cirillo
Alessio Papi
Enzo Spisni
Andrea Vornoli
Clara M. Della Croce
Vincenzo Longo
Paola Franchi
Sandra Filippi
Marco Lucarini
Cristina Zanzi
Francesca Rotondo
Antonello Lorenzini
Silvia Marchionni
Moreno Paolini
author_sort Fabio Vivarelli
title Co-carcinogenic effects of vitamin E in prostate
title_short Co-carcinogenic effects of vitamin E in prostate
title_full Co-carcinogenic effects of vitamin E in prostate
title_fullStr Co-carcinogenic effects of vitamin E in prostate
title_full_unstemmed Co-carcinogenic effects of vitamin E in prostate
title_sort co-carcinogenic effects of vitamin e in prostate
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/dcf912f3c91945589c0624bd7d1c36b9
work_keys_str_mv AT fabiovivarelli cocarcinogeniceffectsofvitamineinprostate
AT donatellacanistro cocarcinogeniceffectsofvitamineinprostate
AT silviacirillo cocarcinogeniceffectsofvitamineinprostate
AT alessiopapi cocarcinogeniceffectsofvitamineinprostate
AT enzospisni cocarcinogeniceffectsofvitamineinprostate
AT andreavornoli cocarcinogeniceffectsofvitamineinprostate
AT claramdellacroce cocarcinogeniceffectsofvitamineinprostate
AT vincenzolongo cocarcinogeniceffectsofvitamineinprostate
AT paolafranchi cocarcinogeniceffectsofvitamineinprostate
AT sandrafilippi cocarcinogeniceffectsofvitamineinprostate
AT marcolucarini cocarcinogeniceffectsofvitamineinprostate
AT cristinazanzi cocarcinogeniceffectsofvitamineinprostate
AT francescarotondo cocarcinogeniceffectsofvitamineinprostate
AT antonellolorenzini cocarcinogeniceffectsofvitamineinprostate
AT silviamarchionni cocarcinogeniceffectsofvitamineinprostate
AT morenopaolini cocarcinogeniceffectsofvitamineinprostate
_version_ 1718387845350031360