CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes

Chromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner. Here the authors identify CENP-V as a microtubule binding and bundling protein crucial to faithful oocyte meiosis, and present Cenp-V−/− oocytes as revealing age-depen...

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Autores principales:	Dalileh Nabi, Hauke Drechsler, Johannes Pschirer, Franz Korn, Nadine Schuler, Stefan Diez, Rolf Jessberger, Mariola Chacón
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dcf979a98c334436b8bb21f92662b1b9
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spelling	oai:doaj.org-article:dcf979a98c334436b8bb21f92662b1b92021-11-14T12:35:37ZCENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes10.1038/s41467-021-26826-32041-1723https://doaj.org/article/dcf979a98c334436b8bb21f92662b1b92021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26826-3https://doaj.org/toc/2041-1723Chromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner. Here the authors identify CENP-V as a microtubule binding and bundling protein crucial to faithful oocyte meiosis, and present Cenp-V−/− oocytes as revealing age-dependent weakening of the spindle assembly checkpoint.Dalileh NabiHauke DrechslerJohannes PschirerFranz KornNadine SchulerStefan DiezRolf JessbergerMariola ChacónNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dalileh Nabi Hauke Drechsler Johannes Pschirer Franz Korn Nadine Schuler Stefan Diez Rolf Jessberger Mariola Chacón CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
description	Chromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner. Here the authors identify CENP-V as a microtubule binding and bundling protein crucial to faithful oocyte meiosis, and present Cenp-V−/− oocytes as revealing age-dependent weakening of the spindle assembly checkpoint.
format	article
author	Dalileh Nabi Hauke Drechsler Johannes Pschirer Franz Korn Nadine Schuler Stefan Diez Rolf Jessberger Mariola Chacón
author_facet	Dalileh Nabi Hauke Drechsler Johannes Pschirer Franz Korn Nadine Schuler Stefan Diez Rolf Jessberger Mariola Chacón
author_sort	Dalileh Nabi
title	CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
title_short	CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
title_full	CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
title_fullStr	CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
title_full_unstemmed	CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
title_sort	cenp-v is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dcf979a98c334436b8bb21f92662b1b9
work_keys_str_mv	AT dalilehnabi cenpvisrequiredforproperchromosomesegregationthroughinteractionwithspindlemicrotubulesinmouseoocytes AT haukedrechsler cenpvisrequiredforproperchromosomesegregationthroughinteractionwithspindlemicrotubulesinmouseoocytes AT johannespschirer cenpvisrequiredforproperchromosomesegregationthroughinteractionwithspindlemicrotubulesinmouseoocytes AT franzkorn cenpvisrequiredforproperchromosomesegregationthroughinteractionwithspindlemicrotubulesinmouseoocytes AT nadineschuler cenpvisrequiredforproperchromosomesegregationthroughinteractionwithspindlemicrotubulesinmouseoocytes AT stefandiez cenpvisrequiredforproperchromosomesegregationthroughinteractionwithspindlemicrotubulesinmouseoocytes AT rolfjessberger cenpvisrequiredforproperchromosomesegregationthroughinteractionwithspindlemicrotubulesinmouseoocytes AT mariolachacon cenpvisrequiredforproperchromosomesegregationthroughinteractionwithspindlemicrotubulesinmouseoocytes
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CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes

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