Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells

Abstract Hydrogen sulphide (H2S) is a colourless gas with the odour of rotten eggs and has recently been recognized as a signal mediator in physiological activities related with the regulation of homeostasis, the vascular system and the inflammatory system. Here we show that H2S donors, including so...

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Autores principales:	Jaehoon Bae, Motofumi Kumazoe, Shuya Yamashita, Hirofumi Tachibana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dcff450aba634dbb8ef22f3ffd973baf
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spelling	oai:doaj.org-article:dcff450aba634dbb8ef22f3ffd973baf2021-12-02T11:40:50ZHydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells10.1038/s41598-017-06879-52045-2322https://doaj.org/article/dcff450aba634dbb8ef22f3ffd973baf2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06879-5https://doaj.org/toc/2045-2322Abstract Hydrogen sulphide (H2S) is a colourless gas with the odour of rotten eggs and has recently been recognized as a signal mediator in physiological activities related with the regulation of homeostasis, the vascular system and the inflammatory system. Here we show that H2S donors, including sodium hydrogen sulphide (NaHS), GYY 4137 and diallyltrisulfide (DATS), synergistically enhanced the anti-cancer effect of a green tea polyphenol (−)-epigallocatechin-3-O-gallate (EGCG) against multiple myeloma cells without affecting normal cells. NaHS significantly potentiated the anti-cancer effect of EGCG and prolonged survival in a mouse xenograft model. In this mechanism, H2S enhanced apoptotic cell death through cyclic guanosine monophosphate (cGMP)/acid sphingomyelinase pathway induced by EGCG. Moreover, NaHS reduced the enzyme activity of cyclic nucleotide phosphodiesterase that is known as cGMP negative regulator. In conclusion, we identified H2S as a gasotransmitter that potentiates EGCG-induced cancer cell death.Jaehoon BaeMotofumi KumazoeShuya YamashitaHirofumi TachibanaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jaehoon Bae Motofumi Kumazoe Shuya Yamashita Hirofumi Tachibana Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells
description	Abstract Hydrogen sulphide (H2S) is a colourless gas with the odour of rotten eggs and has recently been recognized as a signal mediator in physiological activities related with the regulation of homeostasis, the vascular system and the inflammatory system. Here we show that H2S donors, including sodium hydrogen sulphide (NaHS), GYY 4137 and diallyltrisulfide (DATS), synergistically enhanced the anti-cancer effect of a green tea polyphenol (−)-epigallocatechin-3-O-gallate (EGCG) against multiple myeloma cells without affecting normal cells. NaHS significantly potentiated the anti-cancer effect of EGCG and prolonged survival in a mouse xenograft model. In this mechanism, H2S enhanced apoptotic cell death through cyclic guanosine monophosphate (cGMP)/acid sphingomyelinase pathway induced by EGCG. Moreover, NaHS reduced the enzyme activity of cyclic nucleotide phosphodiesterase that is known as cGMP negative regulator. In conclusion, we identified H2S as a gasotransmitter that potentiates EGCG-induced cancer cell death.
format	article
author	Jaehoon Bae Motofumi Kumazoe Shuya Yamashita Hirofumi Tachibana
author_facet	Jaehoon Bae Motofumi Kumazoe Shuya Yamashita Hirofumi Tachibana
author_sort	Jaehoon Bae
title	Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells
title_short	Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells
title_full	Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells
title_fullStr	Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells
title_full_unstemmed	Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells
title_sort	hydrogen sulphide donors selectively potentiate a green tea polyphenol egcg-induced apoptosis of multiple myeloma cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dcff450aba634dbb8ef22f3ffd973baf
work_keys_str_mv	AT jaehoonbae hydrogensulphidedonorsselectivelypotentiateagreenteapolyphenolegcginducedapoptosisofmultiplemyelomacells AT motofumikumazoe hydrogensulphidedonorsselectivelypotentiateagreenteapolyphenolegcginducedapoptosisofmultiplemyelomacells AT shuyayamashita hydrogensulphidedonorsselectivelypotentiateagreenteapolyphenolegcginducedapoptosisofmultiplemyelomacells AT hirofumitachibana hydrogensulphidedonorsselectivelypotentiateagreenteapolyphenolegcginducedapoptosisofmultiplemyelomacells
_version_	1718395551577276416

Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells

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