Radio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital

Background Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor predominantly affecting the pelvis and perineum of females. Due to its variable clinical presentation, it is often misinterpreted and treated as other pathologies like Bartholin gland cyst, vulvar abscess, and hernia. The tumor is l...

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Autores principales:	Ekta Dhamija, Harshal Aswar, Sawyer Ehmad, Adarsh Barwad, Rambha Pandey, Sameer Rastogi
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Materias:	aggressive angiomyxoma laminated appearance sarcoma Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/dd02e003101a47218e421d7f9e8e4f96
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spelling	oai:doaj.org-article:dd02e003101a47218e421d7f9e8e4f962021-11-13T23:32:30ZRadio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital0971-30261998-380810.1055/s-0041-1735913https://doaj.org/article/dd02e003101a47218e421d7f9e8e4f962021-07-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1735913https://doaj.org/toc/0971-3026https://doaj.org/toc/1998-3808Background Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor predominantly affecting the pelvis and perineum of females. Due to its variable clinical presentation, it is often misinterpreted and treated as other pathologies like Bartholin gland cyst, vulvar abscess, and hernia. The tumor is locally infiltrative, making its complete surgical removal difficult. Aim The aim of the study is to highlight and illustrate the imaging and pathological features of AAM. Materials and Methods After obtaining clearance from the Institutional Ethics Committee, a retrospective study was conducted on patients with histopathological diagnosis of AAM, presenting to the dedicated sarcoma clinic between 2016 and 2019. The demographic, clinical, radiological, pathological, and treatment details were obtained from the institute's database. The magnetic resonance imaging (MRI) and computed tomography images were reviewed to assess different imaging parameters. Follow-up imaging was assessed for residual or recurrent mass in the pelvis or perineum and distant metastasis. Results A total of four patients were included with an age range of 28 to 50 years. The baseline MRI of these four patients shows pelvic mass extending into the perineum, infiltrating along the surrounding fascial planes with the characteristic laminated appearance on T2-weighted image and gradual intense enhancement following contrast administration. All patients had residual disease post-surgery and were put on hormonal therapy. Conclusion AAMs are locally aggressive, rarely metastasizing mesenchymal tumor that has a specific predilection for the perineum and pelvis of females. MRI features like laminated or striated appearance, post-contrast enhancement, and finger-like infiltrating projections should raise the suspicion of the diagnosis on baseline imaging.Ekta DhamijaHarshal AswarSawyer EhmadAdarsh BarwadRambha PandeySameer RastogiThieme Medical and Scientific Publishers Pvt. Ltd.articleaggressive angiomyxomalaminated appearancesarcomaMedical physics. Medical radiology. Nuclear medicineR895-920ENIndian Journal of Radiology and Imaging, Vol 31, Iss 03, Pp 566-572 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aggressive angiomyxoma laminated appearance sarcoma Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	aggressive angiomyxoma laminated appearance sarcoma Medical physics. Medical radiology. Nuclear medicine R895-920 Ekta Dhamija Harshal Aswar Sawyer Ehmad Adarsh Barwad Rambha Pandey Sameer Rastogi Radio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital
description	Background Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor predominantly affecting the pelvis and perineum of females. Due to its variable clinical presentation, it is often misinterpreted and treated as other pathologies like Bartholin gland cyst, vulvar abscess, and hernia. The tumor is locally infiltrative, making its complete surgical removal difficult. Aim The aim of the study is to highlight and illustrate the imaging and pathological features of AAM. Materials and Methods After obtaining clearance from the Institutional Ethics Committee, a retrospective study was conducted on patients with histopathological diagnosis of AAM, presenting to the dedicated sarcoma clinic between 2016 and 2019. The demographic, clinical, radiological, pathological, and treatment details were obtained from the institute's database. The magnetic resonance imaging (MRI) and computed tomography images were reviewed to assess different imaging parameters. Follow-up imaging was assessed for residual or recurrent mass in the pelvis or perineum and distant metastasis. Results A total of four patients were included with an age range of 28 to 50 years. The baseline MRI of these four patients shows pelvic mass extending into the perineum, infiltrating along the surrounding fascial planes with the characteristic laminated appearance on T2-weighted image and gradual intense enhancement following contrast administration. All patients had residual disease post-surgery and were put on hormonal therapy. Conclusion AAMs are locally aggressive, rarely metastasizing mesenchymal tumor that has a specific predilection for the perineum and pelvis of females. MRI features like laminated or striated appearance, post-contrast enhancement, and finger-like infiltrating projections should raise the suspicion of the diagnosis on baseline imaging.
format	article
author	Ekta Dhamija Harshal Aswar Sawyer Ehmad Adarsh Barwad Rambha Pandey Sameer Rastogi
author_facet	Ekta Dhamija Harshal Aswar Sawyer Ehmad Adarsh Barwad Rambha Pandey Sameer Rastogi
author_sort	Ekta Dhamija
title	Radio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital
title_short	Radio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital
title_full	Radio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital
title_fullStr	Radio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital
title_full_unstemmed	Radio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital
title_sort	radio-pathological and clinical correlation of aggressive angiomyxoma: experience of a tertiary care cancer hospital
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2021
url	https://doaj.org/article/dd02e003101a47218e421d7f9e8e4f96
work_keys_str_mv	AT ektadhamija radiopathologicalandclinicalcorrelationofaggressiveangiomyxomaexperienceofatertiarycarecancerhospital AT harshalaswar radiopathologicalandclinicalcorrelationofaggressiveangiomyxomaexperienceofatertiarycarecancerhospital AT sawyerehmad radiopathologicalandclinicalcorrelationofaggressiveangiomyxomaexperienceofatertiarycarecancerhospital AT adarshbarwad radiopathologicalandclinicalcorrelationofaggressiveangiomyxomaexperienceofatertiarycarecancerhospital AT rambhapandey radiopathologicalandclinicalcorrelationofaggressiveangiomyxomaexperienceofatertiarycarecancerhospital AT sameerrastogi radiopathologicalandclinicalcorrelationofaggressiveangiomyxomaexperienceofatertiarycarecancerhospital
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Radio-pathological and Clinical Correlation of Aggressive Angiomyxoma: Experience of a Tertiary Care Cancer Hospital

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