Signalling strength determines proapoptotic functions of STING

The cGAS/STING signalling pathway is responsible for sensing intracellular DNA and activating downstream inflammatory genes. Here the authors show mouse primary T cells and T leukaemia are hyperresponsive to STING agonist, and this strong STING signalling is associated with apoptosis induction.

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Autores principales:	Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd0445dd4e334afc9d468d8ec62cb61e
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spelling	oai:doaj.org-article:dd0445dd4e334afc9d468d8ec62cb61e2021-12-02T17:01:18ZSignalling strength determines proapoptotic functions of STING10.1038/s41467-017-00573-w2041-1723https://doaj.org/article/dd0445dd4e334afc9d468d8ec62cb61e2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00573-whttps://doaj.org/toc/2041-1723The cGAS/STING signalling pathway is responsible for sensing intracellular DNA and activating downstream inflammatory genes. Here the authors show mouse primary T cells and T leukaemia are hyperresponsive to STING agonist, and this strong STING signalling is associated with apoptosis induction.Muhammet F. GulenUte KochSimone M. HaagFabian SchulerLionel ApetohAndreas VillungerFreddy RadtkeAndrea AblasserNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Muhammet F. Gulen Ute Koch Simone M. Haag Fabian Schuler Lionel Apetoh Andreas Villunger Freddy Radtke Andrea Ablasser Signalling strength determines proapoptotic functions of STING
description	The cGAS/STING signalling pathway is responsible for sensing intracellular DNA and activating downstream inflammatory genes. Here the authors show mouse primary T cells and T leukaemia are hyperresponsive to STING agonist, and this strong STING signalling is associated with apoptosis induction.
format	article
author	Muhammet F. Gulen Ute Koch Simone M. Haag Fabian Schuler Lionel Apetoh Andreas Villunger Freddy Radtke Andrea Ablasser
author_facet	Muhammet F. Gulen Ute Koch Simone M. Haag Fabian Schuler Lionel Apetoh Andreas Villunger Freddy Radtke Andrea Ablasser
author_sort	Muhammet F. Gulen
title	Signalling strength determines proapoptotic functions of STING
title_short	Signalling strength determines proapoptotic functions of STING
title_full	Signalling strength determines proapoptotic functions of STING
title_fullStr	Signalling strength determines proapoptotic functions of STING
title_full_unstemmed	Signalling strength determines proapoptotic functions of STING
title_sort	signalling strength determines proapoptotic functions of sting
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dd0445dd4e334afc9d468d8ec62cb61e
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Signalling strength determines proapoptotic functions of STING

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