Risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.

<h4>Background</h4>Prospective studies on the risk factors for subarachnoid hemorrhage (SAH) are limited. Moreover, the effect of risk factors on the incidence rates of SAH is not well known about.<h4>Aims</h4>In this study, we aimed to identify risk factors for SAH and chara...

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Autores principales:	Miikka Korja, Karri Silventoinen, Tiina Laatikainen, Pekka Jousilahti, Veikko Salomaa, Juha Hernesniemi, Jaakko Kaprio
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd0b51b2d14f4c17b5cad26daed78676
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spelling	oai:doaj.org-article:dd0b51b2d14f4c17b5cad26daed786762021-11-18T08:56:14ZRisk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.1932-620310.1371/journal.pone.0073760https://doaj.org/article/dd0b51b2d14f4c17b5cad26daed786762013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040058/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Prospective studies on the risk factors for subarachnoid hemorrhage (SAH) are limited. Moreover, the effect of risk factors on the incidence rates of SAH is not well known about.<h4>Aims</h4>In this study, we aimed to identify risk factors for SAH and characterize subgroups in a population with a high incidence of SAH.<h4>Methods</h4>After recording multiple potential risk factors for SAH at the time of enrollment, first ever SAH events between 1972 and 2009 were recorded through the nationwide Causes of Death Register and Hospital Discharge Register for the population-based cohort of 64 349 participants, who participated in the National FINRISK Study between 1972 and 2007 in Finland.<h4>Results</h4>During the follow-up time of 1.26 million person-years (median 17.9 years, range 0 to 37.9 years), 437 persons experienced fatal or non-fatal SAH. Crude SAH incidence was 34.8 (95% confidence interval: 31.7-38.2) per 100 000 person-years among ≥ 25-year-old persons. Female sex, high blood pressure values and current smoking were confirmed as risk factors for SAH. Previous myocardial infarction, history of premature stroke (any kind) in mother and elevated cholesterol levels in men were identified as new risk factors for SAH. Depending on the combination of risk factors, SAH incidence varied between 8 and 171 per 100 000 person-years.<h4>Conclusions</h4>New and previously reported risk factors appear to have a much stronger association with the incidence of SAH than is ordinarily seen in cardiovascular diseases. Risk factor assessments may facilitate the identification of high-risk persons who should be the focus of preventive interventions.Miikka KorjaKarri SilventoinenTiina LaatikainenPekka JousilahtiVeikko SalomaaJuha HernesniemiJaakko KaprioPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73760 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Miikka Korja Karri Silventoinen Tiina Laatikainen Pekka Jousilahti Veikko Salomaa Juha Hernesniemi Jaakko Kaprio Risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.
description	<h4>Background</h4>Prospective studies on the risk factors for subarachnoid hemorrhage (SAH) are limited. Moreover, the effect of risk factors on the incidence rates of SAH is not well known about.<h4>Aims</h4>In this study, we aimed to identify risk factors for SAH and characterize subgroups in a population with a high incidence of SAH.<h4>Methods</h4>After recording multiple potential risk factors for SAH at the time of enrollment, first ever SAH events between 1972 and 2009 were recorded through the nationwide Causes of Death Register and Hospital Discharge Register for the population-based cohort of 64 349 participants, who participated in the National FINRISK Study between 1972 and 2007 in Finland.<h4>Results</h4>During the follow-up time of 1.26 million person-years (median 17.9 years, range 0 to 37.9 years), 437 persons experienced fatal or non-fatal SAH. Crude SAH incidence was 34.8 (95% confidence interval: 31.7-38.2) per 100 000 person-years among ≥ 25-year-old persons. Female sex, high blood pressure values and current smoking were confirmed as risk factors for SAH. Previous myocardial infarction, history of premature stroke (any kind) in mother and elevated cholesterol levels in men were identified as new risk factors for SAH. Depending on the combination of risk factors, SAH incidence varied between 8 and 171 per 100 000 person-years.<h4>Conclusions</h4>New and previously reported risk factors appear to have a much stronger association with the incidence of SAH than is ordinarily seen in cardiovascular diseases. Risk factor assessments may facilitate the identification of high-risk persons who should be the focus of preventive interventions.
format	article
author	Miikka Korja Karri Silventoinen Tiina Laatikainen Pekka Jousilahti Veikko Salomaa Juha Hernesniemi Jaakko Kaprio
author_facet	Miikka Korja Karri Silventoinen Tiina Laatikainen Pekka Jousilahti Veikko Salomaa Juha Hernesniemi Jaakko Kaprio
author_sort	Miikka Korja
title	Risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.
title_short	Risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.
title_full	Risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.
title_fullStr	Risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.
title_full_unstemmed	Risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.
title_sort	risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/dd0b51b2d14f4c17b5cad26daed78676
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Risk factors and their combined effects on the incidence rate of subarachnoid hemorrhage--a population-based cohort study.

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