Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans

Duplications of gene segments can allow novel physiological adaptations to evolve. A detailed analysis of the TCAF gene family in primates and archaic humans suggest rapid duplication and diversification in this gene family is associated with cold or dietary adaptations.

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Autores principales: PingHsun Hsieh, Vy Dang, Mitchell R. Vollger, Yafei Mao, Tzu-Hsueh Huang, Philip C. Dishuck, Carl Baker, Stuart Cantsilieris, Alexandra P. Lewis, Katherine M. Munson, Melanie Sorensen, AnneMarie E. Welch, Jason G. Underwood, Evan E. Eichler
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/dd0c6ba953434ec38b1be1c12780fbb6
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spelling oai:doaj.org-article:dd0c6ba953434ec38b1be1c12780fbb62021-12-02T19:02:36ZEvidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans10.1038/s41467-021-25435-42041-1723https://doaj.org/article/dd0c6ba953434ec38b1be1c12780fbb62021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25435-4https://doaj.org/toc/2041-1723Duplications of gene segments can allow novel physiological adaptations to evolve. A detailed analysis of the TCAF gene family in primates and archaic humans suggest rapid duplication and diversification in this gene family is associated with cold or dietary adaptations.PingHsun HsiehVy DangMitchell R. VollgerYafei MaoTzu-Hsueh HuangPhilip C. DishuckCarl BakerStuart CantsilierisAlexandra P. LewisKatherine M. MunsonMelanie SorensenAnneMarie E. WelchJason G. UnderwoodEvan E. EichlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
PingHsun Hsieh
Vy Dang
Mitchell R. Vollger
Yafei Mao
Tzu-Hsueh Huang
Philip C. Dishuck
Carl Baker
Stuart Cantsilieris
Alexandra P. Lewis
Katherine M. Munson
Melanie Sorensen
AnneMarie E. Welch
Jason G. Underwood
Evan E. Eichler
Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans
description Duplications of gene segments can allow novel physiological adaptations to evolve. A detailed analysis of the TCAF gene family in primates and archaic humans suggest rapid duplication and diversification in this gene family is associated with cold or dietary adaptations.
format article
author PingHsun Hsieh
Vy Dang
Mitchell R. Vollger
Yafei Mao
Tzu-Hsueh Huang
Philip C. Dishuck
Carl Baker
Stuart Cantsilieris
Alexandra P. Lewis
Katherine M. Munson
Melanie Sorensen
AnneMarie E. Welch
Jason G. Underwood
Evan E. Eichler
author_facet PingHsun Hsieh
Vy Dang
Mitchell R. Vollger
Yafei Mao
Tzu-Hsueh Huang
Philip C. Dishuck
Carl Baker
Stuart Cantsilieris
Alexandra P. Lewis
Katherine M. Munson
Melanie Sorensen
AnneMarie E. Welch
Jason G. Underwood
Evan E. Eichler
author_sort PingHsun Hsieh
title Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans
title_short Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans
title_full Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans
title_fullStr Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans
title_full_unstemmed Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans
title_sort evidence for opposing selective forces operating on human-specific duplicated tcaf genes in neanderthals and humans
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/dd0c6ba953434ec38b1be1c12780fbb6
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