Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion

Cerebrovascular pathologies are commonly associated with dementia. Because air pollution increases arterial disease in humans and rodent models, we hypothesized that air pollution would also contribute to brain vascular dysfunction. We examined the effects of exposing mice to nanoparticulate matter...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mikko T. Huuskonen, Qinghai Liu, Krista Lamorie-Foote, Kristina Shkirkova, Michelle Connor, Arati Patel, Axel Montagne, Hans Baertsch, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, Berislav V. Zlokovic, William J. Mack
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	air pollution blood brain barrier hypoperfusion MRI carotid artery stenosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/dd0da04397864fab8976bf2c0b448859
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dd0da04397864fab8976bf2c0b448859
record_format	dspace
spelling	oai:doaj.org-article:dd0da04397864fab8976bf2c0b4488592021-11-16T05:56:33ZAir Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion1664-322410.3389/fimmu.2021.785519https://doaj.org/article/dd0da04397864fab8976bf2c0b4488592021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.785519/fullhttps://doaj.org/toc/1664-3224Cerebrovascular pathologies are commonly associated with dementia. Because air pollution increases arterial disease in humans and rodent models, we hypothesized that air pollution would also contribute to brain vascular dysfunction. We examined the effects of exposing mice to nanoparticulate matter (nPM; aerodynamic diameter ≤200 nm) from urban traffic and interactions with cerebral hypoperfusion. C57BL/6 mice were exposed to filtered air or nPM with and without bilateral carotid artery stenosis (BCAS) and analyzed by multiparametric MRI and histochemistry. Exposure to nPM alone did not alter regional cerebral blood flow (CBF) or blood brain barrier (BBB) integrity. However, nPM worsened the white matter hypoperfusion (decreased CBF on DSC-MRI) and exacerbated the BBB permeability (extravascular IgG deposits) resulting from BCAS. White matter MRI diffusion metrics were abnormal in mice subjected to cerebral hypoperfusion and worsened by combined nPM+BCAS. Axonal density was reduced equally in the BCAS cohorts regardless of nPM status, whereas nPM exposure caused demyelination in the white matter with or without cerebral hypoperfusion. In summary, air pollution nPM exacerbates cerebrovascular pathology and demyelination in the setting of cerebral hypoperfusion, suggesting that air pollution exposure can augment underlying cerebrovascular contributions to cognitive loss and dementia in susceptible elderly populations.Mikko T. HuuskonenQinghai LiuKrista Lamorie-FooteKristina ShkirkovaMichelle ConnorArati PatelAxel MontagneHans BaertschConstantinos SioutasTodd E. MorganCaleb E. FinchBerislav V. ZlokovicWilliam J. MackWilliam J. MackFrontiers Media S.A.articleair pollutionblood brain barrierhypoperfusionMRIcarotid artery stenosisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	air pollution blood brain barrier hypoperfusion MRI carotid artery stenosis Immunologic diseases. Allergy RC581-607
spellingShingle	air pollution blood brain barrier hypoperfusion MRI carotid artery stenosis Immunologic diseases. Allergy RC581-607 Mikko T. Huuskonen Qinghai Liu Krista Lamorie-Foote Kristina Shkirkova Michelle Connor Arati Patel Axel Montagne Hans Baertsch Constantinos Sioutas Todd E. Morgan Caleb E. Finch Berislav V. Zlokovic William J. Mack William J. Mack Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion
description	Cerebrovascular pathologies are commonly associated with dementia. Because air pollution increases arterial disease in humans and rodent models, we hypothesized that air pollution would also contribute to brain vascular dysfunction. We examined the effects of exposing mice to nanoparticulate matter (nPM; aerodynamic diameter ≤200 nm) from urban traffic and interactions with cerebral hypoperfusion. C57BL/6 mice were exposed to filtered air or nPM with and without bilateral carotid artery stenosis (BCAS) and analyzed by multiparametric MRI and histochemistry. Exposure to nPM alone did not alter regional cerebral blood flow (CBF) or blood brain barrier (BBB) integrity. However, nPM worsened the white matter hypoperfusion (decreased CBF on DSC-MRI) and exacerbated the BBB permeability (extravascular IgG deposits) resulting from BCAS. White matter MRI diffusion metrics were abnormal in mice subjected to cerebral hypoperfusion and worsened by combined nPM+BCAS. Axonal density was reduced equally in the BCAS cohorts regardless of nPM status, whereas nPM exposure caused demyelination in the white matter with or without cerebral hypoperfusion. In summary, air pollution nPM exacerbates cerebrovascular pathology and demyelination in the setting of cerebral hypoperfusion, suggesting that air pollution exposure can augment underlying cerebrovascular contributions to cognitive loss and dementia in susceptible elderly populations.
format	article
author	Mikko T. Huuskonen Qinghai Liu Krista Lamorie-Foote Kristina Shkirkova Michelle Connor Arati Patel Axel Montagne Hans Baertsch Constantinos Sioutas Todd E. Morgan Caleb E. Finch Berislav V. Zlokovic William J. Mack William J. Mack
author_facet	Mikko T. Huuskonen Qinghai Liu Krista Lamorie-Foote Kristina Shkirkova Michelle Connor Arati Patel Axel Montagne Hans Baertsch Constantinos Sioutas Todd E. Morgan Caleb E. Finch Berislav V. Zlokovic William J. Mack William J. Mack
author_sort	Mikko T. Huuskonen
title	Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion
title_short	Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion
title_full	Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion
title_fullStr	Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion
title_full_unstemmed	Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion
title_sort	air pollution particulate matter amplifies white matter vascular pathology and demyelination caused by hypoperfusion
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/dd0da04397864fab8976bf2c0b448859
work_keys_str_mv	AT mikkothuuskonen airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT qinghailiu airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT kristalamoriefoote airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT kristinashkirkova airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT michelleconnor airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT aratipatel airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT axelmontagne airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT hansbaertsch airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT constantinossioutas airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT toddemorgan airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT calebefinch airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT berislavvzlokovic airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT williamjmack airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion AT williamjmack airpollutionparticulatematteramplifieswhitemattervascularpathologyanddemyelinationcausedbyhypoperfusion
_version_	1718426697084174336

Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion

Ejemplares similares