PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes

The molecular mechanisms by which free fatty acids (FFA) inhibit muscle glucose oxidation is still elusive. We recently showed that C2C12 myotubes treated with palmitate (PAL) presented with greater protein expression levels of PDK4 and transcription factors <i>PPARα</i> and <i>PPA...

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Bibliographic Details
Main Authors: Hung-Che Chien, Despina Constantin, Paul L. Greenhaff, Dumitru Constantin-Teodosiu
Format: article
Language:EN
Published: MDPI AG 2021
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Online Access:https://doaj.org/article/dd0e320f408a417c96cb06e994deeb33
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