Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.

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Autores principales:	Xiangqi Meng, Yu Zhao, Bo Han, Caijun Zha, Yangong Zhang, Ziwei Li, Pengfei Wu, Tengfei Qi, Chuanlu Jiang, Yang Liu, Jinquan Cai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd170487e7734f4a8de5b105c70b7272
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spelling	oai:doaj.org-article:dd170487e7734f4a8de5b105c70b72722021-12-02T17:31:41ZDual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways10.1038/s41467-019-14036-x2041-1723https://doaj.org/article/dd170487e7734f4a8de5b105c70b72722020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14036-xhttps://doaj.org/toc/2041-1723Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.Xiangqi MengYu ZhaoBo HanCaijun ZhaYangong ZhangZiwei LiPengfei WuTengfei QiChuanlu JiangYang LiuJinquan CaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiangqi Meng Yu Zhao Bo Han Caijun Zha Yangong Zhang Ziwei Li Pengfei Wu Tengfei Qi Chuanlu Jiang Yang Liu Jinquan Cai Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
description	Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.
format	article
author	Xiangqi Meng Yu Zhao Bo Han Caijun Zha Yangong Zhang Ziwei Li Pengfei Wu Tengfei Qi Chuanlu Jiang Yang Liu Jinquan Cai
author_facet	Xiangqi Meng Yu Zhao Bo Han Caijun Zha Yangong Zhang Ziwei Li Pengfei Wu Tengfei Qi Chuanlu Jiang Yang Liu Jinquan Cai
author_sort	Xiangqi Meng
title	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_short	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_full	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_fullStr	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_full_unstemmed	Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
title_sort	dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating egfr and met signaling pathways
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/dd170487e7734f4a8de5b105c70b7272
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Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

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