Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

Receptor tyrosine kinases are often activated in malignant gliomas. Here, the authors develop a dual functionalized brain targeting nano-inhibitor to simultaneously target EGFR and MET pathways, and show this can overcome temozolomide resistance in glioma.

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Autores principales: Xiangqi Meng, Yu Zhao, Bo Han, Caijun Zha, Yangong Zhang, Ziwei Li, Pengfei Wu, Tengfei Qi, Chuanlu Jiang, Yang Liu, Jinquan Cai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/dd170487e7734f4a8de5b105c70b7272
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