Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate

Abstract The exposure of the prostate to high electric field strength during irreversible electroporation (IRE) has been extensively investigated. Multiple monopolar electrodes, however, have risks of organ piercing and bleeding when placing electrodes. A novel bipolar electrode made of pure platinu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bumjin Lim, Hong Bae Kim, Seung Jeong, Song Hee Kim, Jeon Min Kang, Yubeen Park, Dong-Sung Won, Ji Won Kim, Dae Sung Ryu, Yunlim Kim, Jung-Hoon Park, Choung-Soo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd1a64eb9d0e4378aac49d3b4fffbd5b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dd1a64eb9d0e4378aac49d3b4fffbd5b
record_format	dspace
spelling	oai:doaj.org-article:dd1a64eb9d0e4378aac49d3b4fffbd5b2021-12-02T15:09:16ZNovel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate10.1038/s41598-021-96734-52045-2322https://doaj.org/article/dd1a64eb9d0e4378aac49d3b4fffbd5b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96734-5https://doaj.org/toc/2045-2322Abstract The exposure of the prostate to high electric field strength during irreversible electroporation (IRE) has been extensively investigated. Multiple monopolar electrodes, however, have risks of organ piercing and bleeding when placing electrodes. A novel bipolar electrode made of pure platinum and stainless steel was developed for prostate cancer ablation. Voltages of 500 and 700 V were applied to the beagle prostate with this electrode to evaluate ablated tissues and their characteristics. IRE procedures were technically successful in all dogs without procedure-related complications. The current that flowed through the anode and cathode while applying 500 and 700 V were 1.75 ± 0.25 A and 2.22 ± 0.35 A, respectively. TUNEL assays showed that the estimated ablated areas when applying 500 and 700 V were 0.78 cm2 and 1.21 cm2, respectively. The minimum electric field strength threshold required for induction of IRE was 800 V/cm. The platinum electrode was resistant to corrosion. The IRE procedure for beagle prostates using a single bipolar electrode was technically feasible and safe. The novel bipolar electrode has great potential for treating human prostate cancer with fewer IRE-related complications.Bumjin LimHong Bae KimSeung JeongSong Hee KimJeon Min KangYubeen ParkDong-Sung WonJi Won KimDae Sung RyuYunlim KimJung-Hoon ParkChoung-Soo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bumjin Lim Hong Bae Kim Seung Jeong Song Hee Kim Jeon Min Kang Yubeen Park Dong-Sung Won Ji Won Kim Dae Sung Ryu Yunlim Kim Jung-Hoon Park Choung-Soo Kim Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate
description	Abstract The exposure of the prostate to high electric field strength during irreversible electroporation (IRE) has been extensively investigated. Multiple monopolar electrodes, however, have risks of organ piercing and bleeding when placing electrodes. A novel bipolar electrode made of pure platinum and stainless steel was developed for prostate cancer ablation. Voltages of 500 and 700 V were applied to the beagle prostate with this electrode to evaluate ablated tissues and their characteristics. IRE procedures were technically successful in all dogs without procedure-related complications. The current that flowed through the anode and cathode while applying 500 and 700 V were 1.75 ± 0.25 A and 2.22 ± 0.35 A, respectively. TUNEL assays showed that the estimated ablated areas when applying 500 and 700 V were 0.78 cm2 and 1.21 cm2, respectively. The minimum electric field strength threshold required for induction of IRE was 800 V/cm. The platinum electrode was resistant to corrosion. The IRE procedure for beagle prostates using a single bipolar electrode was technically feasible and safe. The novel bipolar electrode has great potential for treating human prostate cancer with fewer IRE-related complications.
format	article
author	Bumjin Lim Hong Bae Kim Seung Jeong Song Hee Kim Jeon Min Kang Yubeen Park Dong-Sung Won Ji Won Kim Dae Sung Ryu Yunlim Kim Jung-Hoon Park Choung-Soo Kim
author_facet	Bumjin Lim Hong Bae Kim Seung Jeong Song Hee Kim Jeon Min Kang Yubeen Park Dong-Sung Won Ji Won Kim Dae Sung Ryu Yunlim Kim Jung-Hoon Park Choung-Soo Kim
author_sort	Bumjin Lim
title	Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate
title_short	Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate
title_full	Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate
title_fullStr	Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate
title_full_unstemmed	Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate
title_sort	novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd1a64eb9d0e4378aac49d3b4fffbd5b
work_keys_str_mv	AT bumjinlim novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT hongbaekim novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT seungjeong novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT songheekim novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT jeonminkang novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT yubeenpark novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT dongsungwon novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT jiwonkim novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT daesungryu novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT yunlimkim novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT junghoonpark novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate AT choungsookim novelplatinumbipolarelectrodeforirreversibleelectroporationinprostatecancerpreclinicalstudyinthebeagleprostate
_version_	1718387845530386432

Novel platinum bipolar electrode for irreversible electroporation in prostate cancer: preclinical study in the beagle prostate

Ejemplares similares