Case Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole

The clinical manifestations of fascioliasis hepatica in humans are unspecific. Traditional diagnosis relies on evidence of live parasites or eggs in the bile or feces. However, due to similar imaging manifestations, they are often misdiagnosed as malignant tumors. Here, we report a case of a 43-year...

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Autores principales:	Yaling Zhang, Huan Xu, Yi Liu, Juan Kang, Hairu Chen, Zhiyi Wang, Dachuan Cai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	case report fascioliasis hepatica metagenomic next-generation sequencing (mNGS) precision treatment albendazole Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/dd1cff727c6b4b57b07c9b6df6819060
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spelling	oai:doaj.org-article:dd1cff727c6b4b57b07c9b6df68190602021-11-30T16:31:45ZCase Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole2296-858X10.3389/fmed.2021.773145https://doaj.org/article/dd1cff727c6b4b57b07c9b6df68190602021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.773145/fullhttps://doaj.org/toc/2296-858XThe clinical manifestations of fascioliasis hepatica in humans are unspecific. Traditional diagnosis relies on evidence of live parasites or eggs in the bile or feces. However, due to similar imaging manifestations, they are often misdiagnosed as malignant tumors. Here, we report a case of a 43-year-old woman with fever and space-occupying liver disease. Liver biopsy, parasite-specific antibody screening, and stool testing did not find any pathogens. Therefore, metagenomic next-generation sequencing (mNGS) and routine microbiological examinations were performed. Finally, Fasciola hepatica was only identified by mNGS. The body temperature of the patient and the eosinophil count remained normal, and the space-occupying liver lesions were significantly absorbed after more than 7 months of treatment with albendazole. The details of this case highlight the timely use of mNGS to identify parasites and judge therapeutic effects after treatment, providing important help for clinical decision-making.Yaling ZhangHuan XuYi LiuJuan KangHairu ChenZhiyi WangDachuan CaiFrontiers Media S.A.articlecase reportfascioliasis hepaticametagenomic next-generation sequencing (mNGS)precision treatmentalbendazoleMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	case report fascioliasis hepatica metagenomic next-generation sequencing (mNGS) precision treatment albendazole Medicine (General) R5-920
spellingShingle	case report fascioliasis hepatica metagenomic next-generation sequencing (mNGS) precision treatment albendazole Medicine (General) R5-920 Yaling Zhang Huan Xu Yi Liu Juan Kang Hairu Chen Zhiyi Wang Dachuan Cai Case Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole
description	The clinical manifestations of fascioliasis hepatica in humans are unspecific. Traditional diagnosis relies on evidence of live parasites or eggs in the bile or feces. However, due to similar imaging manifestations, they are often misdiagnosed as malignant tumors. Here, we report a case of a 43-year-old woman with fever and space-occupying liver disease. Liver biopsy, parasite-specific antibody screening, and stool testing did not find any pathogens. Therefore, metagenomic next-generation sequencing (mNGS) and routine microbiological examinations were performed. Finally, Fasciola hepatica was only identified by mNGS. The body temperature of the patient and the eosinophil count remained normal, and the space-occupying liver lesions were significantly absorbed after more than 7 months of treatment with albendazole. The details of this case highlight the timely use of mNGS to identify parasites and judge therapeutic effects after treatment, providing important help for clinical decision-making.
format	article
author	Yaling Zhang Huan Xu Yi Liu Juan Kang Hairu Chen Zhiyi Wang Dachuan Cai
author_facet	Yaling Zhang Huan Xu Yi Liu Juan Kang Hairu Chen Zhiyi Wang Dachuan Cai
author_sort	Yaling Zhang
title	Case Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole
title_short	Case Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole
title_full	Case Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole
title_fullStr	Case Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole
title_full_unstemmed	Case Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole
title_sort	case report: fascioliasis hepatica precisely diagnosed by metagenomic next-generation sequencing and treated with albendazole
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/dd1cff727c6b4b57b07c9b6df6819060
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Case Report: Fascioliasis Hepatica Precisely Diagnosed by Metagenomic Next-Generation Sequencing and Treated With Albendazole

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