Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism

Diabetes is associated with decreased PI3K activation in skeletal muscle. Here, the authors show that p110a is the predominant PI3K subunit in muscle, and show that its ablation in muscle, but not ablation of p110beta, leads to insulin resistance, increased proteosomal and autophagic activity, and a...

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Autores principales:	Mengyao Ella Li, Hans P. M. M. Lauritzen, Brian T. O’Neill, Chih-Hao Wang, Weikang Cai, Bruna B. Brandao, Masaji Sakaguchi, Rongya Tao, Michael F. Hirshman, Samir Softic, C. Ronald Kahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd1ee7415b94490ba84eaa4f18e22335
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spelling	oai:doaj.org-article:dd1ee7415b94490ba84eaa4f18e223352021-12-02T14:39:00ZRole of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism10.1038/s41467-019-11265-y2041-1723https://doaj.org/article/dd1ee7415b94490ba84eaa4f18e223352019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11265-yhttps://doaj.org/toc/2041-1723Diabetes is associated with decreased PI3K activation in skeletal muscle. Here, the authors show that p110a is the predominant PI3K subunit in muscle, and show that its ablation in muscle, but not ablation of p110beta, leads to insulin resistance, increased proteosomal and autophagic activity, and altered mitochondria homeostasis in mice.Mengyao Ella LiHans P. M. M. LauritzenBrian T. O’NeillChih-Hao WangWeikang CaiBruna B. BrandaoMasaji SakaguchiRongya TaoMichael F. HirshmanSamir SofticC. Ronald KahnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mengyao Ella Li Hans P. M. M. Lauritzen Brian T. O’Neill Chih-Hao Wang Weikang Cai Bruna B. Brandao Masaji Sakaguchi Rongya Tao Michael F. Hirshman Samir Softic C. Ronald Kahn Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
description	Diabetes is associated with decreased PI3K activation in skeletal muscle. Here, the authors show that p110a is the predominant PI3K subunit in muscle, and show that its ablation in muscle, but not ablation of p110beta, leads to insulin resistance, increased proteosomal and autophagic activity, and altered mitochondria homeostasis in mice.
format	article
author	Mengyao Ella Li Hans P. M. M. Lauritzen Brian T. O’Neill Chih-Hao Wang Weikang Cai Bruna B. Brandao Masaji Sakaguchi Rongya Tao Michael F. Hirshman Samir Softic C. Ronald Kahn
author_facet	Mengyao Ella Li Hans P. M. M. Lauritzen Brian T. O’Neill Chih-Hao Wang Weikang Cai Bruna B. Brandao Masaji Sakaguchi Rongya Tao Michael F. Hirshman Samir Softic C. Ronald Kahn
author_sort	Mengyao Ella Li
title	Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
title_short	Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
title_full	Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
title_fullStr	Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
title_full_unstemmed	Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
title_sort	role of p110a subunit of pi3-kinase in skeletal muscle mitochondrial homeostasis and metabolism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dd1ee7415b94490ba84eaa4f18e22335
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Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism

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