A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.

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Detalles Bibliográficos
Autores principales:	Guermarie Velazquez-Torres, Einav Shoshan, Cristina Ivan, Li Huang, Enrique Fuentes-Mattei, Harrison Paret, Sun Jin Kim, Cristian Rodriguez-Aguayo, Victoria Xie, Denise Brooks, Steven J. M. Jones, A. Gordon Robertson, George Calin, Gabriel Lopez-Berenstein, Anil Sood, Menashe Bar-Eli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd20c2509c0c46dbbe02e75f436eee1a
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spelling	oai:doaj.org-article:dd20c2509c0c46dbbe02e75f436eee1a2021-12-02T14:39:23ZA-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression10.1038/s41467-018-02851-72041-1723https://doaj.org/article/dd20c2509c0c46dbbe02e75f436eee1a2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02851-7https://doaj.org/toc/2041-1723In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.Guermarie Velazquez-TorresEinav ShoshanCristina IvanLi HuangEnrique Fuentes-MatteiHarrison ParetSun Jin KimCristian Rodriguez-AguayoVictoria XieDenise BrooksSteven J. M. JonesA. Gordon RobertsonGeorge CalinGabriel Lopez-BerensteinAnil SoodMenashe Bar-EliNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guermarie Velazquez-Torres Einav Shoshan Cristina Ivan Li Huang Enrique Fuentes-Mattei Harrison Paret Sun Jin Kim Cristian Rodriguez-Aguayo Victoria Xie Denise Brooks Steven J. M. Jones A. Gordon Robertson George Calin Gabriel Lopez-Berenstein Anil Sood Menashe Bar-Eli A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
description	In melanoma, reduced ADAR1 impairs A-to-I microRNA editing. Here, the authors show that miR-378a-3p undergoes this editing in non-metastatic cells and the edited form of miR-378a-3p binds to the PARVA oncogene, inhibiting its expression and preventing melanoma progression and metastasis.
format	article
author	Guermarie Velazquez-Torres Einav Shoshan Cristina Ivan Li Huang Enrique Fuentes-Mattei Harrison Paret Sun Jin Kim Cristian Rodriguez-Aguayo Victoria Xie Denise Brooks Steven J. M. Jones A. Gordon Robertson George Calin Gabriel Lopez-Berenstein Anil Sood Menashe Bar-Eli
author_facet	Guermarie Velazquez-Torres Einav Shoshan Cristina Ivan Li Huang Enrique Fuentes-Mattei Harrison Paret Sun Jin Kim Cristian Rodriguez-Aguayo Victoria Xie Denise Brooks Steven J. M. Jones A. Gordon Robertson George Calin Gabriel Lopez-Berenstein Anil Sood Menashe Bar-Eli
author_sort	Guermarie Velazquez-Torres
title	A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_short	A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_full	A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_fullStr	A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_full_unstemmed	A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression
title_sort	a-to-i mir-378a-3p editing can prevent melanoma progression via regulation of parva expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dd20c2509c0c46dbbe02e75f436eee1a
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A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

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