Structural basis of ligand interaction with atypical chemokine receptor 3

The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ligand-induced conformational changes in ACKR3.

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Autores principales:	Martin Gustavsson, Liwen Wang, Noortje van Gils, Bryan S. Stephens, Penglie Zhang, Thomas J. Schall, Sichun Yang, Ruben Abagyan, Mark R. Chance, Irina Kufareva, Tracy M. Handel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd25b21c34a34084a772b436c75162ce
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spelling	oai:doaj.org-article:dd25b21c34a34084a772b436c75162ce2021-12-02T15:37:01ZStructural basis of ligand interaction with atypical chemokine receptor 310.1038/ncomms141352041-1723https://doaj.org/article/dd25b21c34a34084a772b436c75162ce2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14135https://doaj.org/toc/2041-1723The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ligand-induced conformational changes in ACKR3.Martin GustavssonLiwen WangNoortje van GilsBryan S. StephensPenglie ZhangThomas J. SchallSichun YangRuben AbagyanMark R. ChanceIrina KufarevaTracy M. HandelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Gustavsson Liwen Wang Noortje van Gils Bryan S. Stephens Penglie Zhang Thomas J. Schall Sichun Yang Ruben Abagyan Mark R. Chance Irina Kufareva Tracy M. Handel Structural basis of ligand interaction with atypical chemokine receptor 3
description	The atypical chemokine receptor 3 (ACKR3) is important for cell migration in development and cancer. Here the authors combine radiolytic footprinting, disulfide trapping, mutagenesis and molecular modelling to characterize the ligand interactions and ligand-induced conformational changes in ACKR3.
format	article
author	Martin Gustavsson Liwen Wang Noortje van Gils Bryan S. Stephens Penglie Zhang Thomas J. Schall Sichun Yang Ruben Abagyan Mark R. Chance Irina Kufareva Tracy M. Handel
author_facet	Martin Gustavsson Liwen Wang Noortje van Gils Bryan S. Stephens Penglie Zhang Thomas J. Schall Sichun Yang Ruben Abagyan Mark R. Chance Irina Kufareva Tracy M. Handel
author_sort	Martin Gustavsson
title	Structural basis of ligand interaction with atypical chemokine receptor 3
title_short	Structural basis of ligand interaction with atypical chemokine receptor 3
title_full	Structural basis of ligand interaction with atypical chemokine receptor 3
title_fullStr	Structural basis of ligand interaction with atypical chemokine receptor 3
title_full_unstemmed	Structural basis of ligand interaction with atypical chemokine receptor 3
title_sort	structural basis of ligand interaction with atypical chemokine receptor 3
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dd25b21c34a34084a772b436c75162ce
work_keys_str_mv	AT martingustavsson structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT liwenwang structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT noortjevangils structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT bryansstephens structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT pengliezhang structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT thomasjschall structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT sichunyang structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT rubenabagyan structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT markrchance structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT irinakufareva structuralbasisofligandinteractionwithatypicalchemokinereceptor3 AT tracymhandel structuralbasisofligandinteractionwithatypicalchemokinereceptor3
_version_	1718386320177364992

Structural basis of ligand interaction with atypical chemokine receptor 3

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