Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema

Abstract To investigate the pathophysiologic characteristics of diabetic complications, we identified differences in plasma metabolites in subjects with type 2 diabetes (T2DM) with or without diabetic macular edema (DME) and a disease duration > 15 years. An cohort of older T2DM patients with pro...

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Autores principales:	Sang Youl Rhee, Eun Sung Jung, Dong Ho Suh, Su Jin Jeong, Kiyoung Kim, Suk Chon, Seung-Young Yu, Jeong-Taek Woo, Choong Hwan Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd2757cb624c4114b187c47f7b61ce35
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spelling	oai:doaj.org-article:dd2757cb624c4114b187c47f7b61ce352021-12-02T14:29:09ZPlasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema10.1038/s41598-021-88104-y2045-2322https://doaj.org/article/dd2757cb624c4114b187c47f7b61ce352021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88104-yhttps://doaj.org/toc/2045-2322Abstract To investigate the pathophysiologic characteristics of diabetic complications, we identified differences in plasma metabolites in subjects with type 2 diabetes (T2DM) with or without diabetic macular edema (DME) and a disease duration > 15 years. An cohort of older T2DM patients with prolonged disease duration was established, and clinical information and biospecimens were collected following the guidelines of the National Biobank of Korea. DME phenotypes were identified by ophthalmologic specialists. For metabolomics studies, propensity matched case and control samples were selected. To discover multi-biomarkers in plasma, non-targeted metabolite profiling and oxylipin profiling in the discovery cohort were validated in an extended cohort. From metabolomic studies, 5 amino acids (asparagine, aspartic acid, glutamic acid, cysteine, and lysine), 2 organic compounds (citric acid and uric acid) and 4 oxylipins (12-oxoETE, 15-oxoETE, 9-oxoODE, 20-carboxy leukotriene B4) were identified as candidate multi-biomarkers which can guide DME diagnosis among non-DME subjects. Receiver operating characteristic curves revealed high diagnostic value of the combined 5 amino acids and 2 organic compounds (AUC = 0.918), and of the 4 combined oxylipins (AUC = 0.957). Our study suggests that multi-biomarkers may be useful for predicting DME in older T2DM patients.Sang Youl RheeEun Sung JungDong Ho SuhSu Jin JeongKiyoung KimSuk ChonSeung-Young YuJeong-Taek WooChoong Hwan LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sang Youl Rhee Eun Sung Jung Dong Ho Suh Su Jin Jeong Kiyoung Kim Suk Chon Seung-Young Yu Jeong-Taek Woo Choong Hwan Lee Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema
description	Abstract To investigate the pathophysiologic characteristics of diabetic complications, we identified differences in plasma metabolites in subjects with type 2 diabetes (T2DM) with or without diabetic macular edema (DME) and a disease duration > 15 years. An cohort of older T2DM patients with prolonged disease duration was established, and clinical information and biospecimens were collected following the guidelines of the National Biobank of Korea. DME phenotypes were identified by ophthalmologic specialists. For metabolomics studies, propensity matched case and control samples were selected. To discover multi-biomarkers in plasma, non-targeted metabolite profiling and oxylipin profiling in the discovery cohort were validated in an extended cohort. From metabolomic studies, 5 amino acids (asparagine, aspartic acid, glutamic acid, cysteine, and lysine), 2 organic compounds (citric acid and uric acid) and 4 oxylipins (12-oxoETE, 15-oxoETE, 9-oxoODE, 20-carboxy leukotriene B4) were identified as candidate multi-biomarkers which can guide DME diagnosis among non-DME subjects. Receiver operating characteristic curves revealed high diagnostic value of the combined 5 amino acids and 2 organic compounds (AUC = 0.918), and of the 4 combined oxylipins (AUC = 0.957). Our study suggests that multi-biomarkers may be useful for predicting DME in older T2DM patients.
format	article
author	Sang Youl Rhee Eun Sung Jung Dong Ho Suh Su Jin Jeong Kiyoung Kim Suk Chon Seung-Young Yu Jeong-Taek Woo Choong Hwan Lee
author_facet	Sang Youl Rhee Eun Sung Jung Dong Ho Suh Su Jin Jeong Kiyoung Kim Suk Chon Seung-Young Yu Jeong-Taek Woo Choong Hwan Lee
author_sort	Sang Youl Rhee
title	Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema
title_short	Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema
title_full	Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema
title_fullStr	Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema
title_full_unstemmed	Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema
title_sort	plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd2757cb624c4114b187c47f7b61ce35
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Plasma amino acids and oxylipins as potential multi-biomarkers for predicting diabetic macular edema

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