High-precision spatial localization of mouse vocalizations during social interaction

Abstract Mice display a wide repertoire of vocalizations that varies with age, sex, and context. Especially during courtship, mice emit ultrasonic vocalizations (USVs) of high complexity, whose detailed structure is poorly understood. As animals of both sexes vocalize, the study of social vocalizati...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jesse J. Heckman, Rémi Proville, Gert J. Heckman, Alireza Azarfar, Tansu Celikel, Bernhard Englitz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
R
Q
Acceso en línea:https://doaj.org/article/dd29c3da5f0546ac9d6d954ced3606e1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:dd29c3da5f0546ac9d6d954ced3606e1
record_format dspace
spelling oai:doaj.org-article:dd29c3da5f0546ac9d6d954ced3606e12021-12-02T12:32:20ZHigh-precision spatial localization of mouse vocalizations during social interaction10.1038/s41598-017-02954-z2045-2322https://doaj.org/article/dd29c3da5f0546ac9d6d954ced3606e12017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02954-zhttps://doaj.org/toc/2045-2322Abstract Mice display a wide repertoire of vocalizations that varies with age, sex, and context. Especially during courtship, mice emit ultrasonic vocalizations (USVs) of high complexity, whose detailed structure is poorly understood. As animals of both sexes vocalize, the study of social vocalizations requires attributing single USVs to individuals. The state-of-the-art in sound localization for USVs allows spatial localization at centimeter resolution, however, animals interact at closer ranges, involving tactile, snout-snout exploration. Hence, improved algorithms are required to reliably assign USVs. We develop multiple solutions to USV localization, and derive an analytical solution for arbitrary vertical microphone positions. The algorithms are compared on wideband acoustic noise and single mouse vocalizations, and applied to social interactions with optically tracked mouse positions. A novel, (frequency) envelope weighted generalised cross-correlation outperforms classical cross-correlation techniques. It achieves a median error of ~1.4 mm for noise and ~4–8.5 mm for vocalizations. Using this algorithms in combination with a level criterion, we can improve the assignment for interacting mice. We report significant differences in mean USV properties between CBA mice of different sexes during social interaction. Hence, the improved USV attribution to individuals lays the basis for a deeper understanding of social vocalizations, in particular sequences of USVs.Jesse J. HeckmanRémi ProvilleGert J. HeckmanAlireza AzarfarTansu CelikelBernhard EnglitzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jesse J. Heckman
Rémi Proville
Gert J. Heckman
Alireza Azarfar
Tansu Celikel
Bernhard Englitz
High-precision spatial localization of mouse vocalizations during social interaction
description Abstract Mice display a wide repertoire of vocalizations that varies with age, sex, and context. Especially during courtship, mice emit ultrasonic vocalizations (USVs) of high complexity, whose detailed structure is poorly understood. As animals of both sexes vocalize, the study of social vocalizations requires attributing single USVs to individuals. The state-of-the-art in sound localization for USVs allows spatial localization at centimeter resolution, however, animals interact at closer ranges, involving tactile, snout-snout exploration. Hence, improved algorithms are required to reliably assign USVs. We develop multiple solutions to USV localization, and derive an analytical solution for arbitrary vertical microphone positions. The algorithms are compared on wideband acoustic noise and single mouse vocalizations, and applied to social interactions with optically tracked mouse positions. A novel, (frequency) envelope weighted generalised cross-correlation outperforms classical cross-correlation techniques. It achieves a median error of ~1.4 mm for noise and ~4–8.5 mm for vocalizations. Using this algorithms in combination with a level criterion, we can improve the assignment for interacting mice. We report significant differences in mean USV properties between CBA mice of different sexes during social interaction. Hence, the improved USV attribution to individuals lays the basis for a deeper understanding of social vocalizations, in particular sequences of USVs.
format article
author Jesse J. Heckman
Rémi Proville
Gert J. Heckman
Alireza Azarfar
Tansu Celikel
Bernhard Englitz
author_facet Jesse J. Heckman
Rémi Proville
Gert J. Heckman
Alireza Azarfar
Tansu Celikel
Bernhard Englitz
author_sort Jesse J. Heckman
title High-precision spatial localization of mouse vocalizations during social interaction
title_short High-precision spatial localization of mouse vocalizations during social interaction
title_full High-precision spatial localization of mouse vocalizations during social interaction
title_fullStr High-precision spatial localization of mouse vocalizations during social interaction
title_full_unstemmed High-precision spatial localization of mouse vocalizations during social interaction
title_sort high-precision spatial localization of mouse vocalizations during social interaction
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/dd29c3da5f0546ac9d6d954ced3606e1
work_keys_str_mv AT jessejheckman highprecisionspatiallocalizationofmousevocalizationsduringsocialinteraction
AT remiproville highprecisionspatiallocalizationofmousevocalizationsduringsocialinteraction
AT gertjheckman highprecisionspatiallocalizationofmousevocalizationsduringsocialinteraction
AT alirezaazarfar highprecisionspatiallocalizationofmousevocalizationsduringsocialinteraction
AT tansucelikel highprecisionspatiallocalizationofmousevocalizationsduringsocialinteraction
AT bernhardenglitz highprecisionspatiallocalizationofmousevocalizationsduringsocialinteraction
_version_ 1718394126364311552