A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex
Although epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, previous studies have been limited in sample size and brain region used. Here, the authors combine data from six DNA methylomic studies of Alzheimer’s disease (N...
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Nature Portfolio
2021
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oai:doaj.org-article:dd2f5bd2ef1b4cbabe97720ed844e0d62021-12-02T17:47:02ZA meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex10.1038/s41467-021-23243-42041-1723https://doaj.org/article/dd2f5bd2ef1b4cbabe97720ed844e0d62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23243-4https://doaj.org/toc/2041-1723Although epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, previous studies have been limited in sample size and brain region used. Here, the authors combine data from six DNA methylomic studies of Alzheimer’s disease (N = 1453 unique individuals) to identify differentially methylated loci across cortex.Rebecca G. SmithEhsan PishvaGemma ShirebyAdam R. SmithJanou A. Y. RoubroeksEilis HannonGregory WheildonDiego MastroeniGilles GasparoniMatthias RiemenschneiderArmin GieseAndrew J. SharpLeonard SchalkwykVahram HaroutunianWolfgang ViechtbauerDaniel L. A. van den HoveMichael WeedonDanielle BrokawPaul T. FrancisAlan J. ThomasSeth LoveKevin MorganJörn WalterPaul D. ColemanDavid A. BennettPhilip L. De JagerJonathan MillKatie LunnonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q Rebecca G. Smith Ehsan Pishva Gemma Shireby Adam R. Smith Janou A. Y. Roubroeks Eilis Hannon Gregory Wheildon Diego Mastroeni Gilles Gasparoni Matthias Riemenschneider Armin Giese Andrew J. Sharp Leonard Schalkwyk Vahram Haroutunian Wolfgang Viechtbauer Daniel L. A. van den Hove Michael Weedon Danielle Brokaw Paul T. Francis Alan J. Thomas Seth Love Kevin Morgan Jörn Walter Paul D. Coleman David A. Bennett Philip L. De Jager Jonathan Mill Katie Lunnon A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex |
| description |
Although epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, previous studies have been limited in sample size and brain region used. Here, the authors combine data from six DNA methylomic studies of Alzheimer’s disease (N = 1453 unique individuals) to identify differentially methylated loci across cortex. |
| format |
article |
| author |
Rebecca G. Smith Ehsan Pishva Gemma Shireby Adam R. Smith Janou A. Y. Roubroeks Eilis Hannon Gregory Wheildon Diego Mastroeni Gilles Gasparoni Matthias Riemenschneider Armin Giese Andrew J. Sharp Leonard Schalkwyk Vahram Haroutunian Wolfgang Viechtbauer Daniel L. A. van den Hove Michael Weedon Danielle Brokaw Paul T. Francis Alan J. Thomas Seth Love Kevin Morgan Jörn Walter Paul D. Coleman David A. Bennett Philip L. De Jager Jonathan Mill Katie Lunnon |
| author_facet |
Rebecca G. Smith Ehsan Pishva Gemma Shireby Adam R. Smith Janou A. Y. Roubroeks Eilis Hannon Gregory Wheildon Diego Mastroeni Gilles Gasparoni Matthias Riemenschneider Armin Giese Andrew J. Sharp Leonard Schalkwyk Vahram Haroutunian Wolfgang Viechtbauer Daniel L. A. van den Hove Michael Weedon Danielle Brokaw Paul T. Francis Alan J. Thomas Seth Love Kevin Morgan Jörn Walter Paul D. Coleman David A. Bennett Philip L. De Jager Jonathan Mill Katie Lunnon |
| author_sort |
Rebecca G. Smith |
| title |
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex |
| title_short |
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex |
| title_full |
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex |
| title_fullStr |
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex |
| title_full_unstemmed |
A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex |
| title_sort |
meta-analysis of epigenome-wide association studies in alzheimer’s disease highlights novel differentially methylated loci across cortex |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/dd2f5bd2ef1b4cbabe97720ed844e0d6 |
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