Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon

Abstract Participation in an EQA program is critical to the quality assurance process. Reliable and precise CD4 T-cells enumeration are essential to improve the clinical management of patients by evaluating the disease progression and by monitoring the effectiveness of ART in HIV-patients. The CIRCB...

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Autores principales:	Bertrand Sagnia, Sandra Kiazyk, Adrienne F. A. Meyers, Margot Plews, Tamsir O. Diallo, Samuel Martin Sosso, Georgia Ambada, Rachel Kamgaing, Nadesh Nji, Paul Sandstrom, Blake T. Ball, Godwin Nchinda, Alexis Ndjolo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd367a02fc6d4aa7b4bbbab9e34ef0d8
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spelling	oai:doaj.org-article:dd367a02fc6d4aa7b4bbbab9e34ef0d82021-12-02T15:57:03ZEvaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon10.1038/s41598-021-91015-72045-2322https://doaj.org/article/dd367a02fc6d4aa7b4bbbab9e34ef0d82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91015-7https://doaj.org/toc/2045-2322Abstract Participation in an EQA program is critical to the quality assurance process. Reliable and precise CD4 T-cells enumeration are essential to improve the clinical management of patients by evaluating the disease progression and by monitoring the effectiveness of ART in HIV-patients. The CIRCB, CD4 reference laboratory, in collaboration with the Canadian QASI-program, recruited sites, distributed and analyzed CD4-panels in 61 sites across Cameroon. A trend and performance analysis in the pre-analytical, analytical and post-analytical phases was performed. Continuous training and corrective actions carried out from 2014 to 2018 increased the number of participating sites from 15 to 61 sites, the number of unacceptable results decreased from 50 to 10%. Specific challenges included errors in pre analytic (17.5%), analytic (77.0%) and post-analytic (5.5%) phases. This EQA requires the application of good laboratory practices, fluidic communication between all the stakeholders, continuous training, application of specific on-site corrective measures, and timely equipment maintenance in order to avoid repetitive errors and to increase laboratory performance. It could be extended to other HIV-1 testing like viral load and EID point-of-care. Partnership with QASI serve as a model for implementation of a successful EQA model for resource limited countries wanting to implement EQA for HIV testing and monitoring in alignment with 90–90–90 targets.Bertrand SagniaSandra KiazykAdrienne F. A. MeyersMargot PlewsTamsir O. DialloSamuel Martin SossoGeorgia AmbadaRachel KamgaingNadesh NjiPaul SandstromBlake T. BallGodwin NchindaAlexis NdjoloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bertrand Sagnia Sandra Kiazyk Adrienne F. A. Meyers Margot Plews Tamsir O. Diallo Samuel Martin Sosso Georgia Ambada Rachel Kamgaing Nadesh Nji Paul Sandstrom Blake T. Ball Godwin Nchinda Alexis Ndjolo Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon
description	Abstract Participation in an EQA program is critical to the quality assurance process. Reliable and precise CD4 T-cells enumeration are essential to improve the clinical management of patients by evaluating the disease progression and by monitoring the effectiveness of ART in HIV-patients. The CIRCB, CD4 reference laboratory, in collaboration with the Canadian QASI-program, recruited sites, distributed and analyzed CD4-panels in 61 sites across Cameroon. A trend and performance analysis in the pre-analytical, analytical and post-analytical phases was performed. Continuous training and corrective actions carried out from 2014 to 2018 increased the number of participating sites from 15 to 61 sites, the number of unacceptable results decreased from 50 to 10%. Specific challenges included errors in pre analytic (17.5%), analytic (77.0%) and post-analytic (5.5%) phases. This EQA requires the application of good laboratory practices, fluidic communication between all the stakeholders, continuous training, application of specific on-site corrective measures, and timely equipment maintenance in order to avoid repetitive errors and to increase laboratory performance. It could be extended to other HIV-1 testing like viral load and EID point-of-care. Partnership with QASI serve as a model for implementation of a successful EQA model for resource limited countries wanting to implement EQA for HIV testing and monitoring in alignment with 90–90–90 targets.
format	article
author	Bertrand Sagnia Sandra Kiazyk Adrienne F. A. Meyers Margot Plews Tamsir O. Diallo Samuel Martin Sosso Georgia Ambada Rachel Kamgaing Nadesh Nji Paul Sandstrom Blake T. Ball Godwin Nchinda Alexis Ndjolo
author_facet	Bertrand Sagnia Sandra Kiazyk Adrienne F. A. Meyers Margot Plews Tamsir O. Diallo Samuel Martin Sosso Georgia Ambada Rachel Kamgaing Nadesh Nji Paul Sandstrom Blake T. Ball Godwin Nchinda Alexis Ndjolo
author_sort	Bertrand Sagnia
title	Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon
title_short	Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon
title_full	Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon
title_fullStr	Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon
title_full_unstemmed	Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon
title_sort	evaluation of a collaborative model for successful implementation of a national cd4 enumeration eqa program in cameroon
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd367a02fc6d4aa7b4bbbab9e34ef0d8
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Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon

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