STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY

The paper presents results of studying systemic and local level of cytokines in retinal vein occlusion following antiangiogenic therapy. The study of cytokine concentrations was conducted in the general group of patients, and depended on the type of retinal vein occlusion before and after intravitre...

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Autores principales:	E. A. Drozdova, D. Yu. Khokhlova, E. A. Mezentseva, K. V. Nikushkina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	retinal vein occlusion vascular endothelial growth factor interleukin-1 interleukin-6 tumor necrosis factor-α endothelin-1 ranibizumab Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/dd37ac57be064d76a8983edfdd327f30
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spelling	oai:doaj.org-article:dd37ac57be064d76a8983edfdd327f302021-11-18T08:03:47ZSTUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY1563-06252313-741X10.15789/1563-0625-2018-3-365-372https://doaj.org/article/dd37ac57be064d76a8983edfdd327f302018-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1536https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe paper presents results of studying systemic and local level of cytokines in retinal vein occlusion following antiangiogenic therapy. The study of cytokine concentrations was conducted in the general group of patients, and depended on the type of retinal vein occlusion before and after intravitreal injections of Ranibizumab. We examined thirty-two patients with retinal vein occlusion. We performed standard ophthalmological examinations, spectral optical coherence tomography, fluorescent angiography in order to establish the type of retinal vein occlusion. We determined concentration of vascular endothelial growth factor (VEGF), endothelin-1, interleukin-1, interleukin-6 and tumor necrosis factor-α in serum and tears by enzyme immunoassay before treatment, and 3 months after regular injections of Ranibizumab. The obtained data prove that all the patients with retinal vein occlusion had significantly increased VEGF levels in blood serum and tear fluid compared to the control group. We have revealed a positive correlation between levels of VEGF in tear fluid, and interleukin-1, interleukin-6 and endothelin-1 in the tears, as well as with VEGF concentrations and endothelin-1 in serum. We have found an increase of endothelin-1 in tear and serum, alongd with interleukins and tumor necrosis factor-α in tear fluid, with maximal concentrations of some factors in ischemic type of retinal vein occlusion. Following antiangiogenic therapy in patients with non-ischemic type, there was a significant decrease in VEGF level, interleukin-6 and tumor necrosis factor-α in the serum, vascular endothelial growth factor and interleukin-1 in tears. In patients with ischemic type, a significant decrease in VEGF and interleukin-6 concentrations in tears, endothelin-1 and interleukin-1 in blood serum. Thus, our research showed the role of interleukins, tumor necrosis factor-α, vascular endothelial growth factor and endothelin-1 in pathogenesis of retinal vein occlusion.E. A. DrozdovaD. Yu. KhokhlovaE. A. MezentsevaK. V. NikushkinaSPb RAACIarticleretinal vein occlusionvascular endothelial growth factorinterleukin-1interleukin-6tumor necrosis factor-αendothelin-1ranibizumabImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 3, Pp 365-372 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	retinal vein occlusion vascular endothelial growth factor interleukin-1 interleukin-6 tumor necrosis factor-α endothelin-1 ranibizumab Immunologic diseases. Allergy RC581-607
spellingShingle	retinal vein occlusion vascular endothelial growth factor interleukin-1 interleukin-6 tumor necrosis factor-α endothelin-1 ranibizumab Immunologic diseases. Allergy RC581-607 E. A. Drozdova D. Yu. Khokhlova E. A. Mezentseva K. V. Nikushkina STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY
description	The paper presents results of studying systemic and local level of cytokines in retinal vein occlusion following antiangiogenic therapy. The study of cytokine concentrations was conducted in the general group of patients, and depended on the type of retinal vein occlusion before and after intravitreal injections of Ranibizumab. We examined thirty-two patients with retinal vein occlusion. We performed standard ophthalmological examinations, spectral optical coherence tomography, fluorescent angiography in order to establish the type of retinal vein occlusion. We determined concentration of vascular endothelial growth factor (VEGF), endothelin-1, interleukin-1, interleukin-6 and tumor necrosis factor-α in serum and tears by enzyme immunoassay before treatment, and 3 months after regular injections of Ranibizumab. The obtained data prove that all the patients with retinal vein occlusion had significantly increased VEGF levels in blood serum and tear fluid compared to the control group. We have revealed a positive correlation between levels of VEGF in tear fluid, and interleukin-1, interleukin-6 and endothelin-1 in the tears, as well as with VEGF concentrations and endothelin-1 in serum. We have found an increase of endothelin-1 in tear and serum, alongd with interleukins and tumor necrosis factor-α in tear fluid, with maximal concentrations of some factors in ischemic type of retinal vein occlusion. Following antiangiogenic therapy in patients with non-ischemic type, there was a significant decrease in VEGF level, interleukin-6 and tumor necrosis factor-α in the serum, vascular endothelial growth factor and interleukin-1 in tears. In patients with ischemic type, a significant decrease in VEGF and interleukin-6 concentrations in tears, endothelin-1 and interleukin-1 in blood serum. Thus, our research showed the role of interleukins, tumor necrosis factor-α, vascular endothelial growth factor and endothelin-1 in pathogenesis of retinal vein occlusion.
format	article
author	E. A. Drozdova D. Yu. Khokhlova E. A. Mezentseva K. V. Nikushkina
author_facet	E. A. Drozdova D. Yu. Khokhlova E. A. Mezentseva K. V. Nikushkina
author_sort	E. A. Drozdova
title	STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY
title_short	STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY
title_full	STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY
title_fullStr	STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY
title_full_unstemmed	STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY
title_sort	studies of systemic and local cytokine level in retinal vein occlusion associated with antiangiogenic therapy
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/dd37ac57be064d76a8983edfdd327f30
work_keys_str_mv	AT eadrozdova studiesofsystemicandlocalcytokinelevelinretinalveinocclusionassociatedwithantiangiogenictherapy AT dyukhokhlova studiesofsystemicandlocalcytokinelevelinretinalveinocclusionassociatedwithantiangiogenictherapy AT eamezentseva studiesofsystemicandlocalcytokinelevelinretinalveinocclusionassociatedwithantiangiogenictherapy AT kvnikushkina studiesofsystemicandlocalcytokinelevelinretinalveinocclusionassociatedwithantiangiogenictherapy
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STUDIES OF SYSTEMIC AND LOCAL CYTOKINE LEVEL IN RETINAL VEIN OCCLUSION ASSOCIATED WITH ANTIANGIOGENIC THERAPY

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