Integration of sleep homeostasis and navigation in Drosophila.

During sleep, the brain undergoes dynamic and structural changes. In Drosophila, such changes have been observed in the central complex, a brain area important for sleep control and navigation. The connectivity of the central complex raises the question about how navigation, and specifically the hea...

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Autores principales:	Andres Flores-Valle, Pedro J Gonçalves, Johannes D Seelig
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dd393ee0ee8746ebbe7780a6e49461b3
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id	oai:doaj.org-article:dd393ee0ee8746ebbe7780a6e49461b3
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spelling	oai:doaj.org-article:dd393ee0ee8746ebbe7780a6e49461b32021-12-02T19:57:33ZIntegration of sleep homeostasis and navigation in Drosophila.1553-734X1553-735810.1371/journal.pcbi.1009088https://doaj.org/article/dd393ee0ee8746ebbe7780a6e49461b32021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009088https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358During sleep, the brain undergoes dynamic and structural changes. In Drosophila, such changes have been observed in the central complex, a brain area important for sleep control and navigation. The connectivity of the central complex raises the question about how navigation, and specifically the head direction system, can operate in the face of sleep related plasticity. To address this question, we develop a model that integrates sleep homeostasis and head direction. We show that by introducing plasticity, the head direction system can function in a stable way by balancing plasticity in connected circuits that encode sleep pressure. With increasing sleep pressure, the head direction system nevertheless becomes unstable and a sleep phase with a different plasticity mechanism is introduced to reset network connectivity. The proposed integration of sleep homeostasis and head direction circuits captures features of their neural dynamics observed in flies and mice.Andres Flores-VallePedro J GonçalvesJohannes D SeeligPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009088 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Andres Flores-Valle Pedro J Gonçalves Johannes D Seelig Integration of sleep homeostasis and navigation in Drosophila.
description	During sleep, the brain undergoes dynamic and structural changes. In Drosophila, such changes have been observed in the central complex, a brain area important for sleep control and navigation. The connectivity of the central complex raises the question about how navigation, and specifically the head direction system, can operate in the face of sleep related plasticity. To address this question, we develop a model that integrates sleep homeostasis and head direction. We show that by introducing plasticity, the head direction system can function in a stable way by balancing plasticity in connected circuits that encode sleep pressure. With increasing sleep pressure, the head direction system nevertheless becomes unstable and a sleep phase with a different plasticity mechanism is introduced to reset network connectivity. The proposed integration of sleep homeostasis and head direction circuits captures features of their neural dynamics observed in flies and mice.
format	article
author	Andres Flores-Valle Pedro J Gonçalves Johannes D Seelig
author_facet	Andres Flores-Valle Pedro J Gonçalves Johannes D Seelig
author_sort	Andres Flores-Valle
title	Integration of sleep homeostasis and navigation in Drosophila.
title_short	Integration of sleep homeostasis and navigation in Drosophila.
title_full	Integration of sleep homeostasis and navigation in Drosophila.
title_fullStr	Integration of sleep homeostasis and navigation in Drosophila.
title_full_unstemmed	Integration of sleep homeostasis and navigation in Drosophila.
title_sort	integration of sleep homeostasis and navigation in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/dd393ee0ee8746ebbe7780a6e49461b3
work_keys_str_mv	AT andresfloresvalle integrationofsleephomeostasisandnavigationindrosophila AT pedrojgoncalves integrationofsleephomeostasisandnavigationindrosophila AT johannesdseelig integrationofsleephomeostasisandnavigationindrosophila
_version_	1718375811195600896

Integration of sleep homeostasis and navigation in Drosophila.

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