SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

VEGFR2 is a central regulator of angiogenesis. Here Zhou et al. report that SUMOylation of VEGFR2 regulates its subcellular localisation and activity, and that endothelial-specific knockout of the SUMO endopeptidase SENP1 protects against VEGFR2-mediated pathological angiogenesis.

Guardado en:

Detalles Bibliográficos
Autores principales:	Huanjiao Jenny Zhou, Zhe Xu, Zongren Wang, Haifeng Zhang, Zhen W. Zhuang, Michael Simons, Wang Min
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dd3cd77fca9b4bf389b136bb5cc97d80
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:dd3cd77fca9b4bf389b136bb5cc97d80
record_format	dspace
spelling	oai:doaj.org-article:dd3cd77fca9b4bf389b136bb5cc97d802021-12-02T15:34:29ZSUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis10.1038/s41467-018-05812-22041-1723https://doaj.org/article/dd3cd77fca9b4bf389b136bb5cc97d802018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05812-2https://doaj.org/toc/2041-1723VEGFR2 is a central regulator of angiogenesis. Here Zhou et al. report that SUMOylation of VEGFR2 regulates its subcellular localisation and activity, and that endothelial-specific knockout of the SUMO endopeptidase SENP1 protects against VEGFR2-mediated pathological angiogenesis.Huanjiao Jenny ZhouZhe XuZongren WangHaifeng ZhangZhen W. ZhuangMichael SimonsWang MinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huanjiao Jenny Zhou Zhe Xu Zongren Wang Haifeng Zhang Zhen W. Zhuang Michael Simons Wang Min SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
description	VEGFR2 is a central regulator of angiogenesis. Here Zhou et al. report that SUMOylation of VEGFR2 regulates its subcellular localisation and activity, and that endothelial-specific knockout of the SUMO endopeptidase SENP1 protects against VEGFR2-mediated pathological angiogenesis.
format	article
author	Huanjiao Jenny Zhou Zhe Xu Zongren Wang Haifeng Zhang Zhen W. Zhuang Michael Simons Wang Min
author_facet	Huanjiao Jenny Zhou Zhe Xu Zongren Wang Haifeng Zhang Zhen W. Zhuang Michael Simons Wang Min
author_sort	Huanjiao Jenny Zhou
title	SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
title_short	SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
title_full	SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
title_fullStr	SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
title_full_unstemmed	SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
title_sort	sumoylation of vegfr2 regulates its intracellular trafficking and pathological angiogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/dd3cd77fca9b4bf389b136bb5cc97d80
work_keys_str_mv	AT huanjiaojennyzhou sumoylationofvegfr2regulatesitsintracellulartraffickingandpathologicalangiogenesis AT zhexu sumoylationofvegfr2regulatesitsintracellulartraffickingandpathologicalangiogenesis AT zongrenwang sumoylationofvegfr2regulatesitsintracellulartraffickingandpathologicalangiogenesis AT haifengzhang sumoylationofvegfr2regulatesitsintracellulartraffickingandpathologicalangiogenesis AT zhenwzhuang sumoylationofvegfr2regulatesitsintracellulartraffickingandpathologicalangiogenesis AT michaelsimons sumoylationofvegfr2regulatesitsintracellulartraffickingandpathologicalangiogenesis AT wangmin sumoylationofvegfr2regulatesitsintracellulartraffickingandpathologicalangiogenesis
_version_	1718386869231681536

SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

Ejemplares similares