SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

VEGFR2 is a central regulator of angiogenesis. Here Zhou et al. report that SUMOylation of VEGFR2 regulates its subcellular localisation and activity, and that endothelial-specific knockout of the SUMO endopeptidase SENP1 protects against VEGFR2-mediated pathological angiogenesis.

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Autores principales: Huanjiao Jenny Zhou, Zhe Xu, Zongren Wang, Haifeng Zhang, Zhen W. Zhuang, Michael Simons, Wang Min
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/dd3cd77fca9b4bf389b136bb5cc97d80
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