Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain

Abstract To explore the neuroendocrine mechanisms underlying caste-specific behavior and its evolution from primitive to advanced eusocial bees, the monoamine levels and expression of genes involved in monoamine production and signaling in the brain were compared between the castes of Bombus ignitus...

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Autores principales:	Ken Sasaki, Kakeru Yokoi, Kouhei Toga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dd3e18dbcf1f4664806a1befe2ae9e15
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spelling	oai:doaj.org-article:dd3e18dbcf1f4664806a1befe2ae9e152021-12-02T13:20:13ZBumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain10.1038/s41598-021-84992-22045-2322https://doaj.org/article/dd3e18dbcf1f4664806a1befe2ae9e152021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84992-2https://doaj.org/toc/2045-2322Abstract To explore the neuroendocrine mechanisms underlying caste-specific behavior and its evolution from primitive to advanced eusocial bees, the monoamine levels and expression of genes involved in monoamine production and signaling in the brain were compared between the castes of Bombus ignitus. Higher levels of dopamine and its related substances were found in the brains of newly emerged queens than in the brains of emerged workers. The degree of caste differences in B. ignitus was smaller than that reported in Apis mellifera, indicating a link to different social stages in the two species. There was no differential expression in genes involved in dopamine biosynthesis between castes, suggesting that the high dopamine production in queens was not largely influenced by the expression of these genes at emergence, rather it might be influenced by tyrosine supply. Genome-wide analyses of gene expression by RNA-sequencing indicated that a greater number of genes involved in nutrition were actively expressed in the brains of newly emerged queens in comparison to the emerged workers. Some of the expression was confirmed by real-time quantitative PCR. The signaling pathways driven by the expression of these genes may be associated with dopamine signaling or the parallel activation of dopamine production.Ken SasakiKakeru YokoiKouhei TogaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ken Sasaki Kakeru Yokoi Kouhei Toga Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain
description	Abstract To explore the neuroendocrine mechanisms underlying caste-specific behavior and its evolution from primitive to advanced eusocial bees, the monoamine levels and expression of genes involved in monoamine production and signaling in the brain were compared between the castes of Bombus ignitus. Higher levels of dopamine and its related substances were found in the brains of newly emerged queens than in the brains of emerged workers. The degree of caste differences in B. ignitus was smaller than that reported in Apis mellifera, indicating a link to different social stages in the two species. There was no differential expression in genes involved in dopamine biosynthesis between castes, suggesting that the high dopamine production in queens was not largely influenced by the expression of these genes at emergence, rather it might be influenced by tyrosine supply. Genome-wide analyses of gene expression by RNA-sequencing indicated that a greater number of genes involved in nutrition were actively expressed in the brains of newly emerged queens in comparison to the emerged workers. Some of the expression was confirmed by real-time quantitative PCR. The signaling pathways driven by the expression of these genes may be associated with dopamine signaling or the parallel activation of dopamine production.
format	article
author	Ken Sasaki Kakeru Yokoi Kouhei Toga
author_facet	Ken Sasaki Kakeru Yokoi Kouhei Toga
author_sort	Ken Sasaki
title	Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain
title_short	Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain
title_full	Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain
title_fullStr	Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain
title_full_unstemmed	Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain
title_sort	bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dd3e18dbcf1f4664806a1befe2ae9e15
work_keys_str_mv	AT kensasaki bumblebeequeensactivatedopamineproductionandgeneexpressioninnutritionalsignalingpathwaysinthebrain AT kakeruyokoi bumblebeequeensactivatedopamineproductionandgeneexpressioninnutritionalsignalingpathwaysinthebrain AT kouheitoga bumblebeequeensactivatedopamineproductionandgeneexpressioninnutritionalsignalingpathwaysinthebrain
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Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain

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